Dr. Mare Cudic

Dr. Mare Cudic

Ph.D. University of Zagreb, 1996

Professor Director of Honors in Chemistry Program

Chemistry & Biochemistry

Boca Raton, SE 134

p: 561-297-4645

mcudic@fau.edu

https://chemistry.fau.edu/mclab/mclab.php

Research Interests

The main emphasis of our research is to better understand protein-carbohydrate interactions involved in many important physiological and pathological processes. We use chemical approaches to synthesize model glycopeptides and glycopeptide libraries as tools for probing glycan biology. This research may have implications in the development of novel more effective disease-modifying therapeutic strategies for cancer and neurodegenerative diseases such as Alzheimer’s disease.

Awards and Recognition

2024    The Researcher of the Year, College of Science, FAU

2023    The Distinguished Mentor of the Year Award, FAU

2019    The Distinguished Mentor of the Year Award, College of Science, FAU

Recent Publications

  1. Y. Singh, D. Regmi, D. Ormaza, R. Ayyalasomayajula, N. Vela, G. Mundim, D. Du, D. Minond, and M. Cudic (2022) “Mucin-type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate.” Front. Chem., 10:859822  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023740/

  2. D. M. Beckwith, F. G. FitzGerald, M. C. Rodriguez Benavente, E. R. Mercer, A. K. Ludwig, M. Michalak, H. Kaltner, J. Kopitz, H.-J. Gabius, M. Cudic (2021) “Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin.”, Biochemistry, 60:547-558  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8269692/

  3. Y. Singh, D. Ormaza, A. Massetti, D. Minond, and M. Cudic (2021) “Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides.” ACS Chem. Neurosci., 12:2974-2980.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378340/

  4. Y. Singh, M. C. Rodriguez Benavente, M. H. Al-Huniti, D. Beckwith, R. Ayyalasomayajula, E. Patino, W. S. Miranda, A. Wade, and M. Cudic (2020) “Positional Scanning MUC1 Glycopeptide Library Reveals the Importance of PDTR Epitope Glycosylation for Lectin Binding.” J. Org. Chem. 85:1434-1445.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012140/

  5. F. G. FitzGerald, M. C. Rodriguez Benavente, C. Garcia, Y. Rivero, Y. Singh, H. Wang, G. B. Fields, M. Cudic (2020) “TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution.” Glycoconj. J. 37:657-666.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680447/

  6. J. J. Lohmueller, S. Sato, L. Popova, I. M. Chu, M. Tucker, R. Barberena, G. Innocenti,  M. Cudic, J. D. Ham, W. Cheung, R. D. Polakiewicz, and O. J. Finn(2016) Human anti-MUC1 monoclonal antibodies produced by healthy individuals in response to a prophylactic cancer vaccine: tumor specificity and immunotherapeutic potential,  Nature Sci. Rep.  6   :  31740. PMID: 27545199 http://www.nature.com/articles/srep31740

  7. A. Jakas, M. Perc, J. Suć, M. C. Rodriguez,  M. Cudic, and P. Cudic (2016) Synthesis of Anthrose lipidic derivative as mimic of  B. anthracis  BclA glycoprotein for use in ELISA-like binding assays,  J. Carbohydr. Chem.   35:69-85. http://www.tandfonline.com/doi/full/10.1080/07328303.2016.1139124

  8. M. C. Rodriguez, S. Yegorova, J-P. Pitteloud, A. E. Chavaroche, S. André, A. Ardá, D. Minond, J. Jiménez-Barbero, H-J. Gabius,and  M. Cudic  (2015) “Thermodynamic switch in binding of adhesion/growth-regulatory human galectin-3 to tumor-associated TF antigen and MUC1 glycopeptides.”  Biochemistry,  54:4462-74. PMCID:4520625 http://pubs.acs.org/doi/abs/10.1021/acs.biochem.5b00555

  9. S. Yegorova, A. A. E. Chavaroche, M. C. Rodriguez, D. Minond,  M. Cudic  (2012) “Analysis of low affinity glycan-lectin interactions using AlphaScreen technology.”  Anal Biochem.   439: 123-131. PMID: 15705169 http://www.sciencedirect.com/science/article/pii/S0003269713002194

  10. A. Yongye, L. Calle, A. Arda, J. Jimenez-Barbero, S. André, H.-J. Gabius, K. Martinez-Mayorga, and  M. Cudic  (2012) “Molecular Recognition of TF antigen-Threonine Conjugate by Adhesion/Growth Regulatory Galectin-3: NMR Studies and Molecular Dynamics Simulations.”  Biochemistry   51: 7278-7289. PMID: 22916968  http://pubs.acs.org/doi/abs/10.1021/bi300761s

Other Information

  • Member Editorial Board, Frontiers in Chemistry, Chemical Biology

  • Member, National Certification Exam Committee, American Society for Biochemistry and Molecular Biology (ASBMB)

  • Member, American Chemical Society

  • Member, Society for Glycobiology

  • Member, American Peptide Society

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