Sylvia I. Gografe, D.V.M., Ph.D.

Biography

Sylvia Gografe, D.V.M., Ph.D., Research Associate Professor of Biomedical Science and Director of Comparative Medicine. Dr. Gografe has more than 25 years of experience in veterinary medicine and animal research having held academic and administrative appointments with Oklahoma Medical Research Foundation, Vanderbilt University, Bay Pines Veterans Administration and the University of South Florida. She is licensed to practice in Florida, Oklahoma and the European Union. Dr. Gografe achieved specialty board certification as a Diplomate with the American College of Laboratory Animal Medicine (ACLAM) in 2005. She maintains an active interest in collaborative research, has multiple publications and presentations promoting laboratory animal medicine.

Education

• 1986: Diplomveterinaermediziner (DVM,) University of Leipzig, Germany
• 1994: Ph.D., Microbiology/Food Sanitation, University of Leipzig, Germany
• 1995: Internship, Department of Epidemiology/Microbiology, University of Leipzig, Germany School of Medicine

Work History

• 2013-Present: Research Associate Professor of Biomedical Science, Department of Integrated Medical Science, College of Medicine, FAU
• 2012-Present: Attending Veterinarian and Director, Comparative Medicine, Florida Atlantic University, Boca Raton, FL
• 2005-Present: Attending Veterinarian and Consulting Veterinary Medical Officer, Bay Pines Veterans Administration, VA Medical Center, Bay Pines, FL
• 2012: Consulting and Interim Attending Veterinarian, Max Planck Florida Institute, Jupiter, FL
• 2010-2012: Attending Veterinarian and Director, Department of Comparative Medicine, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK
• 2010-2012: Associate Member, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK
• 2010-2011: Consulting and Attending Veterinarian, Genzyme, Oklahoma City, OK
• 2007-2010: Director, Office of Animal Welfare Assurance, Vanderbilt University Nashville, TN
• 2007-2010: Assistant Professor, Department of Pathology, School of Medicine Vanderbilt University
• 2005-2011: Animal Core Director and PI of Core B, Program Project Grant, Center of Excellence for Aging and Brain Repair, University of South Florida
• 2004-2006: Assistant Professor, Department of Pathology, School of Medicine, University of South Florida
• 2001-2004: Research Associate, Department of Pathology, School of Medicine, University of South Florida
• 1998-2006: Clinical Veterinarian, Division of Comparative Medicine, University of South Florida
• 1998-2001: Visiting Assistant, Department of Pathology, School of Medicine, University of South Florida
• 1996-1997: Department Head/Director of the Microbiological Laboratory, Institute of Food, Water and Environmental Analysis Dr. Schwarz, Nuremberg, Germany
• 1990-1995: Veterinarian Supervisor, City of Leipzig, Public Veterinary and Health Department, Germany
• 1987-1989; Veterinarian Supervisor – Meat Inspection, County Meat Processing and Packing Plant, Leipzig, Germany

Scholarly Activity

Peer-Reviewed Publications

• SI Gografe, BC Hansen, KD Hansen: Treatment of Conjunctivitis via Subconjunctival Injection in Macaques (Macaca mulatta and Macaca fascicularis). Lab Animal 44(3): 92-96. 2015
• LNG Nilsson, S Gografe, DA Costa, T Hughes, D Dressler, H Potter: Use of Fused Circulation to Investigate the Role of Apolipoprotein E as Amyloid Catalyst and Peripheral Sink In Alzheimer's Disease. Technology and Innovation 14(2): 199-208. 2012
• WG Marshall, Jr, BA Boone, JD Burgos, SI Gografe, MK Baldwin, ML Danielson, MJ Larson, DR Caretto, Y Cruz, B Ferraro, LC Heller, KE Ugen, MJ Jaroszeski, and R Heller: Electroporation Mediated Delivery of a Naked DNA Plasmid Expressing VEGF to the Porcine Heart Enhances Protein Expression. Gene Therapy 17(3): 419-423. 2010
• SI Gografe, PR Sanberg, W Chamizo, H Monforte, S Garbuzova-Davis: Novel Pathological Findings Associated with Urinary Retention in a Mouse Model of Sanfilippo Syndrome Type B. Comparative Medicine 59(2): 139-146. 2009
• S Garbuzova-Davis, SI Gografe, C Davis Sanberg, AE Willing, S Saporta, DF Cameron, T Dejarlais, J Daily, N Kuzmin-Nichols, W Chamizo, SK Klasko, PR Sanberg: MaternalTransplantation of Human Umbilical Cord Blood Cells Provides Prenatal Therapy in Sanfilippo Type B Mouse Model. FASEB Journal 20(3):485-7. 2006.
• SI Gografe, S Garbuzova-Davis, AE Willing, K Haas, W Chamizo, PR Sanberg: Mouse Model of Sanfilippo Syndrome Type B: Relation of Phenotypic Features to Background Strain. Comparative Medicine 53(6): 622-32. 2003.
• SI Gografe, JS Wilson, BL Johnson, G Rushing, A Bowser, JL Parker, CE Cornelius: Successful Management of Long-Term General Anesthesia in Rabbits Used as an Animal Model of Human Disease. Contemporary Topics 42(2). 16-19. 2003.
• JK Lindzey, WR Gower, HR Mushinsky, UE Owens, LB Graham, SI Gografe, JH VanEtten, RW Engelman: A Unique Application to the IACUC for Studies of Wild Animals in or from Natural Settings. Contemporary Topics 41(6), 33-36. 2002.
• Sylvia Gografe (Krueger), K. Fehlhaber, G. Schiefer: Investigations into the Quality of Various Types of Frankfurters and Liver Sausage Sold in Leipzig From the Point of View of Consumer Protection. Fleisch 48, 560-64 and 645-49. 1994.
• Schulz, J. Steinbacher, W. Siebert, Sylvia Gografe (Krueger): Relationship between Udder Health and Raw Milk Quality, With Particular Reference to Electric Conductivity and Soxleth-Henkel-Number. Mh. Vet. Med. 42, 545-49. 1987.

Books

• SI Gografe (Ed.) AALAS Mouse Handbook. American Association for Laboratory Animal Science, Memphis, TN. 2006.

Book chapters

• SI Gografe, E Orchard: Institutional Animal Care and Use Committee (IACUC). In: LH Toledo-Pereyra (Ed.) Principles of Research from Idea to Publication. Nova Science Publishers. NY. 2013.
• SI Gografe: Medicine. In: SI Gografe (ed.) AALAS Mouse Handbook. American Association for Laboratory Animal Science, Memphis, TN. 2006.

Brief Communications

• M Holmes and S Gografe: Protecting Welfare or Obstructing Research? Protecting Animal Welfare, Protocol Review Column. Lab Animal 42 (10):356. 2013
• SI Gografe: Grants for Laboratory Animal Science Program: 2009 GLAS Awards Announced.JAALAS 48 (3): 320, 2009.
• SI Gografe and S Barlow: Grants for Laboratory Animal Science Program: A Call for Support of Future Awardees.JAALAS 48 (2): 218, 2009.
• DD Myers and SI Gografe: Grants for Laboratory Animal Science Program: A Funding Source to Enhance Scientific Knowledge in Laboratory Animal Science through Research. JAALAS 47 (6): 186-188. 2008

Professional Documents

• SI Gografe, MA Niekrasz, JM Raber:Cranial Implant Care Guidelines for Nonhuman Primates in Biomedical Research, Association of Primate Veterinarians, www.primatevets.org , 2015.

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Professional Organizations

• International Veterinary Academy of Pain Management
• American Veterinary Medical Association
• American Association for Laboratory Animal Science
• Association of Primate Veterinarians
• American Society of Laboratory Animal Practitioners
• Academy of Surgical Research

Professional Activities

• 2012-Present: Institutional Animal Care and Use Committee, Florida Atlantic University
• 2005-Present: Animal Studies Subcommittee (IACUC), Bay Pines VA Medical Center, Bay Pines, FL2012-Present: American College of Laboratory Animal Medicine Governmental Relations Committee
• 2012: Institutional Animal Care and Use Committee, Max-Planck-Florida-Institute
• 2010-2012: Institutional Animal Care and Use Committee, OMRF
• American Association of Laboratory Animal Science (AALAS)
  • 2009 – 2012: Governmental Relations Committee, American Association of Laboratory Animal Science
  • 2011-2012: Oklahoma Branch of AALAS, Trustee
  • 2004-2009: Scientific Advisory Committee, American Association of Laboratory Animal Science
    • Vice Chair, 2007/08
    • Chair, 2008/2009
  • 2007-2009: Grant Review Committee for Scientific Advisory Committee of AALAS
• 2009-2011: Association of Primate Veterinarians, Education Committee
• 2009-2010: Compliance Research Group, Vanderbilt University
• 2007-2010: Institutional Animal Care and Use Committee (IACUC) Vanderbilt University
• 2009: American Association of Laboratory Animal Sciences Chair and Organizer AALAS Symposium Nonhuman Primate Models of Diabetes: Progression and Treatment.
• 2009: American Association of Laboratory Animal Sciences Organizer, Symposium Welfare Considerations in Animal Models of Diabetes
• 2009: American Association of Laboratory Animal Sciences Chair and Organizer, AALAS Panel Discussion Grants for Laboratory Animal Science: Tips for Successful Applications
• 2009: Association for Primate Veterinarians Chair and Organizer. APV Special Topic Lecture Care of Chronic Cranial Implants in Nonhuman Primates
• 2007-08: Compliance Operations Committee, Vanderbilt University
• 2006: Standard Setting Study Committee, American College of Laboratory Animal Medicine
• 2004-06: Subcommittee on Research Safety at the James A. Haley VA Medical Center, Tampa, FL
• 2005 Committee of Inquiry, Research and Development Service, James A. Haley VA Medical Center, Tampa, FL
• 2005: USF, Health Science Center – Research Day Committee, Invited Judge
• 2002-04: Institutional Animal Care and Use Committee (IACUC), University of South Florida
• 2004: Association of Laboratory Animal Sciences Chair and Organizer, AALAS Symposium Emerging Techniques in Control of Pain and Distress in NHP in Experimentation
• 2003-04: AALAS National Meeting – Local Arrangements Subcommittee (NM-LAC)
• 1999-2004: Research and Development Committee at the James A. Haley VA Medical Center
• 1999-2002: Subcommittee on Research Safety at the James A. Haley VA Medical Center

Journal Review

• 2007-2010: Reviewer, Journal of Medical Primatology
• 2010-Present: Reviewer, Journal of Visualized Experiments (JoVE)
• 2009-Present: Reviewer, Journal Comparative Medicine
• 2007-Present: Reviewer, Journal of the American Association of Laboratory Animal Science
• 2008: Reviewer, Institute of Laboratory Animal Research (ILAR)
• 2005: Reviewer on the Scientific Review Committee of the ACVIM Foundation

Grant Review

• 2014: Ad Hoc Reviewer, Harbor Branch Oceanographic Institute (FAU-HBOI), State License Plate Programs Protect Florida Whales and Protect Wild Dolphins
• AALAS Grants for Laboratory Animal Science
  • 2007 - 2009: Review Committee
  • Ad Hoc Reviewer

Teaching Activities

• 2012-Present: Establishment and Development of Training Program for Institution-Wide Animal Care and Research Personnel, Florida Atlantic University, Boca Raton, FL
• 2006-Present: Lecturer, Annual Training Course for researchers and research technicians, Bay Pines VA Medical Center
• 2012: Lecturer, Graduate Course – Care and Use of Research Animals, Oklahoma University, Oklahoma City, OK
• 2010-2012: Establishment and Development of Training Program for Animal Care and Research Personnel, OMRF
• 2008-2010: Establishment and Development of Institution-wide Training Program for Research Personnel working with Laboratory Animals in Research, VU
• 2008-2010: Lecturer, New Faculty Orientation – Using Animals in Research or Teaching
• 2008-2010: Lecturer, Master of Science for Clinical Investigation Course - Research Ethics and Scientific Integrity, VU
• 2009: Lecturer, Course "MSCI - Research Ethics and Scientific Integrity", VU
• 2009: Lecturer, Workshop for Graduate Students “Ethics in Science”

Experimentation

• 2009: Lecturer, Course “An Organ Systems Approach to Experimental Targeting of The Metabolic Syndrome”
• 2009: Tutor, Speed Mentoring, IACUC/PRIM&R Conference
• 2008: Lecturer, Introduction into Regulatory Requirements for Working with Animals in Research and Teaching, Interdisciplinary Graduate Program, VU
• 2008: Lecturer, Master of Laboratory Investigation Course – Laboratory Management, VU
• 2008: Medical Scientist Training Program, Responsible Conduct in Research, VU
• 2008: Lecturer, AALAS Technician Certification Course, VU
• 2005-2006: Lecturer, Veterinary College, University of Leipzig, Leipzig, Germany
• 2000-2006: Lecturer, The Honors Course in Surgery for Medical Students, USF
• 2002: Practical Instructor, Cardiac, Pulmonary, Gastro-intestinal Anatomy Laboratory for Graduate Students, USF
• 1998-2001: Tutor, LAT/LATG Training Classes
• 1996-1997: Tutor/Lecturer in Continuing Education Courses for Technical Staff of the Institute of Food, Water and Environmental Analysis Dr. Schwarz, Nuremberg, Germany
• 1992-1995: Course Leader and Lecturer, Course - Laws and Regulations in Public Health Service, City of Leipzig, Public Veterinary and Health Department, Leipzig, Germany
• 1987-1989: Lecturer, Continuing Education Courses for Meat Inspectors

Other Significant Activities: (Research)

• 2007-2012: Evaluation of Status Quo of Care of Chronic Cranial Implants i Non-human Primates
• 2006-2011: Aminergic Function in Brain Aging and Alzheimer’s Disease
• 2004-2007: Stem Cells in Tissue Repair after Cardiac Injury
• 2003-2006: Prenatal Treatment of Sanfilippo Syndrome Type IIIB with Umbilical Cord Blood Cells
• 2000-2006: Exploration of the Contribution of Circulating Proteins to Alzheimer Amyloid Formation via Blood Transfer by the Means of Parabiosis between Different Strains of Mice which Express Distinct Proteins whether in the Blood or Brain
• 2002-2006: Mouse Model of Sanfilippo Syndrome Type B: Phenotypic Abnormalities
• 2001-2003: Induction of Ovarian Cancer in a Rabbit Model
• 2001-2002: The Effects of Dichloroacetate in a Rabbit Model of Acute Hind Limb Ischemia and Reperfusion
• 1992-1194: Microbiological, Biochemical, Anatomic-Histological, and Sensory Investigations into the Quality of Various Food Items
• 1983-1986: Relationship between Udder Health and Raw Milk Quality in Cows

Dissertation Committees

• April 2006, Liesl Wiesen, M.S., Environmental Sciences
  Department of Environmental Science and Policy
  College of Arts and Sciences, University of South Florida, Tampa, FL
  Thesis: Blood Lead Concentrations in the Cat Population of Tampa

Facility Support

• NIH: Expanding Excellence in Developmental Biology in Oklahoma. Role in Project: Director Animal Facilities ($300,000 awarded for “Alteration and Renovation”) Grant#: 1P20GM103636-01A1, $2,820,000 (PI Linda Thompson, Ph.D.), 03/2013-02/2018

Completed Research Support

• NIH: Aminergic Function in Brain Aging and Alzheimer’s Disease
  Grant#: 5PO1 AG-04418-26, (PI Paula Bickford, Ph.D.) - $5,485,000
  07/2006-06/2011
  Role: Animal Core Director and PI of Core B
  
  
• Alzheimer’s Association: Role of Circulating Proteins in Alzheimer’s Disease
  Grant #: 7909000RO, (PI Huntington Potter, Ph.D)
  08/2005-07/2008
  Role: Veterinary Surgeon
  
  
• Florida Hi-Tech Corridor External Matching Grant: Cord Blood: Treatment for Acute Myocardial Infarction
  05/05 – 10/07 (PI William Marshall, Jr., MD)
  Role: Veterinary Surgeon/Cardiac Ultrasound
  
  
• NIH/NHLBI Phase I STTR Grant: Cord Blood: Treatment for Acute Myocardial Infarction
  Grant #: 1R41 HL077012-01A1, (PI William Marshall, Jr., MD)
  05/2005 – 4/2007
  Role: Veterinary Surgeon/Cardiac Ultrasound
  
  
• Alzheimer’s Association: Role of Circulating Proteins in Alzheimer’s Disease
  Grant #: 6111389LO, (PI Huntington Potter)
  09/2001--08/2005
  Role: Veterinary Surgery
  

Patents

• Garbuzova-Davis SN, Sanberg PR, Gografe SI. A novel method of prenatal administration of mammalian umbilical cord stem cells for intrauterine treatment of mammalian lysosomal storage diseases. Invention. USF-004PRO, 2005.