Publications
Elesclomol Diminishes Redox Imbalance in Peripheral Tissues of Mblac1 Knockout Mice.
Neghabi M, Nategh P, Stauffer AM, Hahn MK, Blakely RD, Ranji M.
J Biophotonics. 2026 Jan;19(1):e70224. doi: 10.1002/jbio.70224.
PMID: 41548934
Peripheral Inflammation Limits Serotonin Neuron Signaling Capacity via Serotonergic IL-1R1 to Reduce Neuronal Excitability and Enhance Serotonin Clearance
P. A. Gajewski, H. Iwamoto, A. N. Tillman, Z. Filliben, A. E. Walsh, N. L. Baganz, M. J. Robson, M. Zapata, N.Quan, R. D. Blakely
bioRxiv 2025.10.13.682078; doi: https://doi.org/10.1101/2025.10.13.682078
Elesclomol-Mediated Alterations of Liver Metabolism in the Context of Mouse Mblac1 Disruption
Nategh P, Neghabi M, Stauffer AM, R. D. Blakely, Ranji M.
Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-4. doi: 10.1109/EMBC58623.2025.11254869.
PMID: 41335708
The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction
Stewart A, Blakely RD
Adv Neurobiol. 2025;46:235-270. doi: 10.1007/978-3-031-96364-3_10.
PMID: 41051713
Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant.
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S.
Mol Psychiatry. 2025 May 29. doi: 10.1038/s41380-025-03055-4. Online ahead of print.
PMID: 40442453
Localization of brain neuronal IL-1R1 reveals specific neural circuitries responsive to immune signaling.
Nemeth DP, Liu X, Monet MC, Niu H, Maxey G, Schrier MS, Smirnova MI, McGovern SJ, Herd A, DiSabato DJ, Floyd T, Atluri RR, Nusstein AC, Oliver B, Witcher KG, Juste Ellis JS, Yip J, Crider AD, McKim DB, Gajewski-Kurdziel PA, Godbout JP, Zhang Q, Blakely RD, Sheridan JF, Quan N.
J Neuroinflammation. 2024 Nov 19;21(1):303. doi: 10.1186/s12974-024-03287-1.
PMID: 39563437
Forward genetic screen of the C. elegans million mutation library reveals essential, cell-autonomous contributions of BBSome proteins to dopamine signaling.
Refai O, Rodriguez P, Gichi Z, Blakely RD.
J Neurochem. 2024 Sep;168(9):2073-2091. doi: 10.1111/jnc.16188. Epub 2024 Aug 8.
PMID: 39118406
Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis.
Rodriguez P, Kalia V, Fenollar-Ferrer C, Gibson CL, Gichi Z, Rajoo A, Matier CD, Pezacki AT, Xiao T, Carvelli L, Chang CJ, Miller GW, Khamoui AV, Boerner J, Blakely RD.
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2320611121. doi: 10.1073/pnas.2320611121. Epub 2024 Sep 17.
PMID: 39288174
Sink or swim: Does a worm paralysis phenotype hold clues to neurodegenerative disease?
Rodriguez P, Blakely RD.
J Cell Physiol. 2024 Jun;239(6):e31125. doi: 10.1002/jcp.31125. Epub 2023 Oct 5.
PMID: 37795580
Forward genetic screen of the C. elegans million mutation library reveals essential, cell-autonomous contributions of BBSome proteins to dopamine signaling.
Refai O, Rodriguez P, Gichi Z, Blakely RD.
Front Mol Biosci. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259. eCollection 2024. J Neurochem. 2024 Aug 8. doi: 10.1111/jnc.16188.
PMID: 39118406
Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI.
Chen Y, Lu X, Whitney RL, Li Y, Robson MJ, Blakely RD, Chi JT, Crowley SD, Privratsky JR.
Front Mol Biosci. 2024 Apr 17;11:1366259. doi: 10.3389/fmolb.2024.1366259. eCollection 2024.
PMID: 38693918
Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration.
Anderson GM, Cook EH, Blakely RD, Sutcliffe JS, Veenstra-VanderWeele J.J
Inflamm Res. 2024 Apr 11;17:2169-2172. doi: 10.2147/JIR.S456000. eCollection 2024.
PMID: 38628604
Simple Rescue of Opaque Tissue Previously Cleared by iDISCO.
Mesa H, Meade J, Gajewski-Kurdziel P, Blakely RD, Zhang Q.
Bio Protoc. 2024 Mar 5;14(5):e4948. doi: 10.21769/BioProtoc.4948. eCollection 2024 Mar 5.
PMID: 38464943
Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease.
Mayer FP, Stewart A, Blakely RD.
Basic Clin Pharmacol Toxicol. 2024 Feb;134(2):206-218. doi: 10.1111/bcpt.13964. Epub 2023 Dec 6.
PMID: 37987120
Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice.
Ceyhan B, Nategh P, Neghabi M, LaMar JA, Konjalwar S, Rodriguez P, Hahn MK, Gross M, Grumbar G, Salleng KJ, Blakely RD, Ranji M.
IEEE J Transl Eng Health Med. 2024 Jan 15;12:298-305. doi: 10.1109/JTEHM.2024.3355962. eCollection 2024.
PMID: 38410184
Functional and pathological consequences of being fast on the uptake: Protein kinase G and p38α MAPK regulation of serotonin transporters.
Gajeswski-Kurdziel PA, Walsh AE, Blakely RD.
Curr Res Physiol. 2024 Jan 4;7:100117. doi: 10.1016/j.crphys.2024.100117. eCollection 2024.
PMID: 38298474
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors.
Gradisch R, Schlögl K, Lazzarin E, Niello M, Maier J, Mayer FP, Alves da Silva L, Skopec SMC, Blakely RD, Sitte HH, Mihovilovic MD, Stockner T.
Nat Commun. 2024 Jan 10;15(1):417. doi: 10.1038/s41467-023-44637-6.
PMID: 38195746
Optical Imaging Reveals Liver Metabolic Perturbations in Mblac1 Knockout Mice.
Ceyhan B, LaMar J, Nategh P, Neghabi M, Konjalwar S, Rodriguez P, Hahn MK, Blakely RD, Ranji M.
Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10341032.
PMID: 38083729
Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.
Luis TC, Barkas N, Carrelha J, Giustacchini A, Mazzi S, Norfo R, Wu B, Aliouat A, Guerrero JA, Rodriguez-Meira A, Bouriez-Jones T, Macaulay IC, Jasztal M, Zhu G, Ni H, Robson MJ, Blakely RD, Mead AJ, Nerlov C, Ghevaert C, Jacobsen
SEW.Nat Commun. 2023 Sep 28;14(1):6062. doi: 10.1038/s41467-023-41691-y.
PMID: 37770432
Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells.
Haque TT, Taruselli MT, Kee SA, Dailey JM, Pondicherry N, Gajewski-Kurdziel PA, Zellner MP, Stephenson DJ, MacKnight HP, Straus DB, Kankaria R, Jackson KG, Chumanevich AP, Fukuoka Y, Schwartz LB, Blakely RD, Oskeritzian CA, Chalfant CE, Martin RK, Ryan JJ.
Sci Signal. 2023 Sep 12;16(802):eabc9089. doi: 10.1126/scisignal.abc9089. Epub 2023 Sep 12.
PMID: 37699080
Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder.
Støier JF, Jørgensen TN, Sparsø T, Rasmussen HB, Kumar V, Newman AH, Blakely RD, Werge T, Gether U, Herborg F.
medRxiv. 2023 Aug 29:2023.08.29.23294386. doi: 10.1101/2023.08.29.23294386. Preprint.
PMID: 37693601 Free PMC article.
Divergent Actions of Renal Tubular and Endothelial Type 1 IL-1 Receptor Signaling in Toxin-Induced AKI.
Ren J, Liu K, Wu B, Lu X, Sun L, Privratsky JR, Xing C, Robson MJ, Mao H, Blakely RD, Abe K, Souma T, Crowley SD.
J Am Soc Nephrol. 2023 Aug 7. doi: 10.1681/ASN.0000000000000191. Online ahead of print.
PMID: 37545036
Kappa Opioid Receptor Antagonism Rescues Genetic Perturbation of Dopamine Homeostasis: Molecular, Physiological and Behavioral Consequences.
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S.
bioRxiv. 2023 May 3:2023.05.03.539310. doi: 10.1101/2023.05.03.539310. Preprint.
PMID: 37205452
Serotonin in the orbitofrontal cortex enhances cognitive flexibility.
Hyun JH, Hannan P, Iwamoto H, Blakely RD, Kwon HB.
bioRxiv. 2023 Mar 9:2023.03.09.531880. doi: 10.1101/2023.03.09.531880. Preprint.
PMID: 36945634
Serotonin-releasing agents with reduced off-target effects.
Mayer FP, Niello M, Cintulova D, Sideromenos S, Maier J, Li Y, Bulling S, Kudlacek O, Schicker K, Iwamoto H, Deng F, Wan J, Holy M, Katamish R, Sandtner W, Li Y, Pollak DD, Blakely RD, Mihovilovic MD, Baumann MH, Sitte HH.
Mol Psychiatry. 2023 Feb;28(2):722-732. doi: 10.1038/s41380-022-01843-w. Epub 2022 Nov 9.
PMID: 36352123
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
Ren J, Lu X, Hall G, Privratsky JR, Robson MJ, Blakely RD, Crowley SD.
Am J Physiol Renal Physiol. 2022 Feb 1;322(2):F164-F174. doi: 10.1152/ajprenal.00353.2021. Epub 2021 Dec 13.
PMID: 34894725
Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo.
Meinke C, Quinlan MA, Paffenroth KC, Harrison FE, Fenollar-Ferrer C, Katamish RM, Stillman I, Ramamoorthy S, Blakely RD.
Neurochem Res. 2022 Jan;47(1):37-60. doi: 10.1007/s11064-021-03299-w. Epub 2021 Apr 8.
PMID: 33830406
Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters.
Stewart A, Mayer FP, Gowrishankar R, Davis GL, Areal LB, Gresch PJ, Katamish RM, Peart R, Stilley SE, Spiess K, Rabil MJ, Diljohn FA, Wiggins AE, Vaughan RA, Hahn MK, Blakely RD.
Mol Psychiatry. 2022 Dec;27(12):4869-4880. doi: 10.1038/s41380-022-01773-7. Epub 2022 Sep 18.
PMID: 36117213
Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes.
Stewart A, Davis GL, Areal LB, Rabil MJ, Tran V, Mayer FP, Blakely RD.
Cells. 2022 Dec 15;11(24):4059. doi: 10.3390/cells11244059.
PMID: 36552823
Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1.
Refai O, Aggarwal S, Cheng MH, Gichi Z, Salvino JM, Bahar I, Blakely RD, Mortensen OV.
Mol Pharmacol. 2022 Mar;101(3):123-131. doi: 10.1124/molpharm.121.000400. Epub 2021 Dec 14.
PMID: 34906999
Disrupted Choline Clearance and Sustained Acetylcholine Release In Vivo by a Common Choline Transporter Coding Variant Associated with Poor Attentional Control in Humans.
Donovan E, Avila C, Klausner S, Parikh V, Fenollar-Ferrer C, Blakely RD, Sarter M.
J Neurosci. 2022 Apr 20;42(16):3426-3444. doi: 10.1523/JNEUROSCI.1334-21.2022. Epub 2022 Mar 1.
PMID: 35232764
Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse.
Stilley SE, Blakely RD.Front Cell Neurosci. 2021 Jun 3;15:677563. doi: 10.3389/fncel.2021.677563. eCollection 2021.
PMID: 34149362
Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo.
Meinke C, Quinlan MA, Paffenroth KC, Harrison FE, Fenollar-Ferrer C, Katamish RM, Stillman I, Ramamoorthy S, Blakely RD.Neurochem Res. 2021 Apr 8. doi: 10.1007/s11064-021-03299-w. Online ahead of print.
PMID: 33830406
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders.
Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA.Cell Rep. 2021 Feb 2;34(5):108718.
Serotonin 5-HT1B receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant.
O'Reilly KC, Connor M, Pierson J, Shuffrey LC, Blakely RD, Ahmari SE, Veenstra-VanderWeele J.Psychopharmacology (Berl). 2021 Apr;238(4):1111-1120. doi: 10.1007/s00213-020-05758-8. Epub 2021 Jan 29.
PMID: 33511450
There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens.
Mayer FP, Iwamoto H, Hahn MK, Grumbar GJ, Stewart A, Li Y, Blakely RD.Neurochem Int. 2021 Jan;142:104894.
Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin.
Hersey M, Samaranayake S, Berger SN, Tavakoli N, Mena S, Nijhout HF, Reed MC, Best J, Blakely RD, Reagan LP, Hashemi P.J Neurosci. 2021 Jul 28;41(30):6564-6577. doi: 10.1523/JNEUROSCI.2618-20.2021. Epub 2021 Jun 3.
PMID: 34083254
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Quinlan MA, Robson MJ, Ye R, Rose KL, Schey KL, Blakely RD. Front Mol Neurosci.
2020 Jun 8;13:89. doi: 10.3389/fnmol.2020.00089. eCollection 2020.
PMID: 32581705
A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant.
O'Reilly KC, Anacker AMJ, Rogers TD, Forsberg CG, Wang J, Zhang B, Blakely RD, Veenstra-VanderWeele J.Neurosci Lett.
2020 May 11;730:135027. doi: 10.1016/j.neulet.2020.135027. Online ahead of print.
PMID: 32437898
Neurobehavioral changes arising from early life dopamine signaling perturbations.
Areal LB, Blakely RD.Neurochem Int. 2020 Jul;137:104747. doi: 10.1016/j.neuint.2020.104747. Epub 2020 Apr 20.
PMID: 32325191
Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits.
Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry RJ, Tan T, Ellegood J, Basson MA, Blakely RD, Dindot SV, Golzio C, Hahn MK, Katsanis N, Robins DM, Silverman JL, Singh KK, Wevrick R, Taylor MJ, Hammill C, Anagnostou E, Pfeiffer BE, Stoodley CJ, Lerch JP, du Lac S, Tsai PT.Nat Neurosci. 2020 Sep;23(9):1102-1110.
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Quinlan MA, Robson MJ, Ye R, Rose KL, Schey KL, Blakely RD.Front Mol Neurosci. 2020 Jun 8;13:89. doi: 10.3389/fnmol.2020.00089.
A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant.
O'Reilly KC, Anacker AMJ, Rogers TD, Forsberg CG, Wang J, Zhang B, Blakely RD, Veenstra-VanderWeele J.Neurosci Lett. 2020 Jun 21;730:135027.
Neurobehavioral changes arising from early life dopamine signaling perturbations.
Areal LB, Blakely RD.Neurochem Int. 2020 Jul;137:104747. doi: 10.1016/j.neuint.2020.104747. Epub 2020 Apr 20.PMID: 32325191 Review.
Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.
Robinson SB, Refai O, Hardaway JA, Sturgeon S, Popay T, Bermingham DP, Freeman P, Wright J, Blakely RD.
PLoS One. 2019 May 13;14(5):e0216417. doi: 10.1371/journal.pone.0216417. eCollection 2019.
PMID: 31083672
Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.
Koshy Cherian A, Tronson NC, Parikh V, Kucinski A, Blakely RD, Sarter M.
Behav Neurosci. 2019 Mar 21. doi: 10.1037/bne0000310. [Epub ahead of print]
PMID:30896190
Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N.
Immunity. 2019 Mar 19;50(3):764-766. doi: 10.1016/j.immuni.2019.02.012. No abstract available.
PMID:30893590
The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action.
Simmler LD, Blakely RD.
ACS Chem Neurosci. 2019 Mar 13. doi: 10.1021/acschemneuro.9b00005. [Epub ahead of print]
PMID:30817127
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Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.
Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N.
Immunity. 2019 Feb 19;50(2):317-333.e6. doi: 10.1016/j.immuni.2018.12.012. Epub 2019 Jan 22. Erratum in: Immunity. 2019 Mar 19;50(3):764-766.
PMID:30683620
Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.
Quinlan MA, Krout D, Katamish RM, Robson MJ, Nettesheim C, Gresch PJ, Mash DC, Henry LK, Blakely RD.
ACS Chem Neurosci. 2019 Feb 5. doi: 10.1021/acschemneuro.8b00689. [Epub ahead of print]
PMID:30668912
Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice.
Stewart A, Davis GL, Gresch PJ, Katamish RM, Peart R, Rabil MJ, Gowrishankar R, Carroll FI, Hahn MK, Blakely RD.
Neuropsychopharmacology. 2019 Apr;44(5):994-1006. doi: 10.1038/s41386-018-0301-8. Epub 2018 Dec 21.
PMID:30578419
The brain in flux: Genetic, physiologic, and therapeutic perspectives on transporters in the CNS.
Blakely RD, El Mestikawy S, Robinson MB.
Neurochem Int. 2019 Feb;123:1-6. doi: 10.1016/j.neuint.2018.12.006. Epub 2018 Dec 17.
PMID:30571999
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.. Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, Watterson DM, Blakely RD. Proc Natl Acad Sci U S A. 2018 Oct 8. pii: 201809137. doi: 10.1073/pnas.1809137115. [Epub ahead of print] PMID: 30297392
Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM. Pharmacol Res. 2018 Jun 9. pii: S1043-6618(18)30429-8. doi: 10.1016/j.phrs.2018.06.008. [Epub ahead of print] PMID: 29894763
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation. Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ. Mol Metab. 2018 Jun 6. pii: S2212-8778(18)30304-1. doi: 10.1016/j.molmet.2018.06.003. [Epub ahead of print]
Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM. Pharmacol Res. 2018 Jun 9. pii: S1043-6618(18)30429-8. doi: 10.1016/j.phrs.2018.06.008. [Epub ahead of print] PMID: 29894763
Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1. Gibson CL, Codreanu SG, Schrimpe-Rutledge AC, Retzlaff CL, Wright J, Mortlock DP, Sherrod SD, McLean JA, Blakely RD. Mol Omics. 2018 Jun 12;14(3):142-155. doi: 10.1039/c7mo00022g. PMID: 29868674
Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone. Refai O, Blakely RD. Neurochem Int. 2018 May 22. pii: S0197-0186(18)30169-4. doi: 10.1016/j.neuint.2018.05.013. [Epub ahead of print] PMID: 29800604
Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559. Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD. J Neurosci. 2018 Jun 6;38(23):5302-5312. doi: 10.1523/JNEUROSCI.0055-18.2018. Epub 2018 May 8. PMID: 29739866
Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging. Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP. Mol Autism. 2018 Apr 10;9:24. doi: 10.1186/s13229-018-0210-z. eCollection 2018. PMID: 29651330
Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Gibson CL, Balbona JT, Niedzwiecki A, Rodriguez P, Nguyen KCQ, Hall DH, Blakely RD. PLoS Genet. 2018 Mar 28;14(3):e1007269. doi: 10.1371/journal.pgen.1007269. eCollection 2018 Mar. PMID: 29590100
Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, Chioza BA, Blakely RD, Chilton JK, De Bleecker J, Baets J, Baple EL, Walk D, Crosby AH. Neurol Genet. 2018 Mar 23;4(2):e222. doi: 10.1212/NXG.0000000000000222. eCollection 2018 Apr. PMID: 29582019
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. Erratum in: Cell Rep. 2018 Jul 24;24(4):1081-1084. PMID: 29298426
Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. Dai H, Jackson CR, Davis GL, Blakely RD, McMahon DG. J Neurodev Disord. 2017 Dec 28;9(1):38. doi: 10.1186/s11689-017-9215-8. PMID: 29281965
Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, Sejersen T, Wright J, Zimmerman HH, Karakaya M, Stüve B, Weis J, Schara U, Russell MA, Abdul-Rahman OA, Chilton J, Blakely RD, Baple EL, Cirak S, Crosby AH. Brain. 2017 Nov 1;140(11):2838-2850. doi: 10.1093/brain/awx249. PMID: 29088354
Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD. Behav Brain Res. 2018 Jan 30;337:61-69. doi: 10.1016/j.bbr.2017.09.043. Epub 2017 Sep 28. PMID: 28964912
Spatial gene expression analysis of neuroanatomical differences in mouse models. Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Neuroimage. 2017 Dec;163:220-230. doi: 10.1016/j.neuroimage.2017.08.065. Epub 2017 Sep 4. PMID: 28882630
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism. Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM 3rd, Blakely RD. J Neurosci. 2017 Sep 20;37(38):9288-9304. doi: 10.1523/JNEUROSCI.1582-17.2017. Epub 2017 Aug 21. PMID: 28842414
Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. Retzlaff CL, Kussrow A, Schorkopf T, Saetear P, Bornhop DJ, Hardaway JA, Sturgeon SM, Wright J, Blakely RD. ACS Chem Neurosci. 2017 Oct 18;8(10):2132-2138. doi: 10.1021/acschemneuro.7b00232. Epub 2017 Aug 14. PMID: 28783953
Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity. Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M. Neurochem Int. 2017 Sep;108:410-416. doi: 10.1016/j.neuint.2017.05.022. Epub 2017 May 31. PMID: 28577989
Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response. Brindley RL, Bauer MB, Blakely RD, Currie KPM. ACS Chem Neurosci. 2017 May 17;8(5):943-954. doi: 10.1021/acschemneuro.7b00026. Epub 2017 Apr 13. Review. PMID: 28406285
Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. Robson MJ, Quinlan MA, Blakely RD. ACS Chem Neurosci. 2017 May 17;8(5):932-942. doi: 10.1021/acschemneuro.6b00412. Epub 2017 Apr 3. Review. PMID: 28345868
An autism-associated serotonin transporter variant disrupts multisensory processing. Siemann JK, Muller CL, Forsberg CG, Blakely RD, Veenstra-VanderWeele J, Wallace MT. Transl Psychiatry. 2017 Mar 21;7(3):e1067. doi: 10.1038/tp.2017.17. PMID: 28323282
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M. J Neurosci. 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13. PMID: 28193693
Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Bermingham DP, Blakely RD. Pharmacol Rev. 2016 Oct;68(4):888-953. doi: 10.1124/pr.115.012260. Review. PMID: 27591044
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bertron JL, Ennis EA, Tarr CJ, Wright J, Dickerson JW, Locuson CW, Blobaum AL, Rook JM, Blakely RD, Lindsley CW. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-4640. doi: 10.1016/j.bmcl.2016.08.062. Epub 2016 Aug 21. PMID: 27575469
Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility. Sarter M, Lustig C, Blakely RD, Koshy Cherian A. J Physiol Paris. 2016 Sep;110(1-2):10-18. doi: 10.1016/j.jphysparis.2016.07.001. Epub 2016 Jul 9. Review. PMID: 27404793
Spatial gene expression analysis of neuroanatomical differences in mouse models. Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Lerch JP. Neuroimage. 2017 Sep 4. pii: S1053-8119(17)30721-8. doi: 10.1016/j.neuroimage.2017.08.065. [Epub ahead of print] PMID: 28882630
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters Through a Rho-Dependent Mechanism.Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM 3rd, Blakely RD. J Neurosci. 2017 Aug 21. pii: 1582-17. doi: 10.1523/JNEUROSCI.1582-17.2017. [Epub ahead of print] PMID: 28842414
Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. Retzlaff CL, Kussrow A, Schorkopf T, Saetear P, Bornhop DJ, Hardaway JA, Sturgeon SM, Wright J, Blakely RD. ACS Chem Neurosci. 2017 Aug 14. doi: 10.1021/acschemneuro.7b00232. [Epub ahead of print] PMID: 28783953
Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD, Blakely RD, Bonnin A, Veenstra-VanderWeele J. Neuropsychopharmacology. 2017 Jan;42(2):427-436. doi: 10.1038/npp.2016.166. Epub 2016 Aug 23. PMID: 27550733
Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Rajkowska G, Mahajan G, Legutko B, Challagundla L, Griswold M, Albert PR, Daigle M, Miguel-Hidalgo JJ, Austin MC, Blakely RD, Steffens DC, Stockmeier CA. Neuroscience. 2017 Jul 13. pii: S0306-4522(17)30476-1. doi: 10.1016/j.neuroscience.2017.07.006. [Epub ahead of print]
Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD. Br J Pharmacol. 2017 Jun 5. doi: 10.1111/bph.13899. [Epub ahead of print] PMID: 28585320
Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity. Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M. Neurochem Int. 2017 Sep;108:410-416. doi: 10.1016/j.neuint.2017.05.022. Epub 2017 May 31. PMID: 28577989
Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response. Brindley RL, Bauer MB, Blakely RD, Currie KPM. ACS Chem Neurosci. 2017 May 17;8(5):943-954. doi: 10.1021/acschemneuro.7b00026. Epub 2017 Apr 13. PMID: 28406285
Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. Robson MJ, Quinlan MA, Blakely RD. ACS Chem Neurosci. 2017 May 17;8(5):932-942. doi: 10.1021/acschemneuro.6b00412. Epub 2017 Apr 3. PMID: 28345868
An autism-associated serotonin transporter variant disrupts multisensory processing. Siemann JK, Muller CL, Forsberg CG, Blakely RD, Veenstra-VanderWeele J, Wallace MT. Transl Psychiatry. 2017 Mar 21;7(3):e1067. doi: 10.1038/tp.2017.17. PMID: 28323282 Free PMC Article
Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse.Nackenoff AG, Simmler LD, Baganz NL, Pehrson AL, Sánchez C, Blakely RD. ACS Chem Neurosci. 2017 May 17;8(5):1092-1100. doi: 10.1021/acschemneuro.7b00038. Epub 2017 Mar 20. PMID: 28272863
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M. J Neurosci. 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13. PMID: 28193693
Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization. Robinson SB, Hardaway JA, Hardie SL, Wright J, Glynn RM, Bermingham DP, Han Q, Sturgeon SM, Freeman P, Blakely RD. Mol Cell Neurosci. 2017 Jan;78:41-51. doi: 10.1016/j.mcn.2016.11.011. Epub 2016 Nov 30. PMID: 27913309
Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology. 2016 Jun;41(7):1733-41. doi: 10.1038/npp.2015.335. Epub 2015 Oct 30. PMID: 26514584; PubCentral PMCID: PMC4869040.
Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25. PMID: 27111230
Ennis EA, Blakely RD. Choline on the Move: Perspectives on the Molecular Physiology and Pharmacology of the Presynaptic Choline Transporter. Adv Pharmacol. 2016;76:175-213. doi: 10.1016/bs.apha.2016.03.001. Epub 2016 Apr 7. PMID: 27288078
Iwamoto H, Calcutta MW, Blakely RD. Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine. Neurochem Int. 2016 Mar 22. pii: S0197-0186(16)30038-9. doi: 10.1016/j.neuint.2016.03.012. [Epub ahead of print] PMID: 27013347
Robson MJ, Zhu CB, Quinlan MA, Botschner DA, Baganz NL, Lindler KM, Thome JG, Hewlett WA, Blakely RD. Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. PLoS One. 2016 Mar 1;11(3):e0150068. doi: 10.1371/journal.pone.0150068. eCollection 2016. PubMed PMID: 26930558; PubMed Central PMCID: PMC4773179.
Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD. Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. Neurochem Int. 2016 Feb 3. pii: S0197 0186(16)30008-0. doi: 10.1016/j.neuint.2016.01.008. [Epub ahead of print] PubMed PMID: 26850478.
Ye R, Quinlan MA, Iwamoto H, Wu HH, Green NH, Jetter CS, McMahon DG, Veestra-VanderWeele J, Levitt P, Blakely RD. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Front Synaptic Neurosci. 2016 Jan 11;7:20. doi: 10.3389/fnsyn.2015.00020. eCollection 2015. PubMed PMID: 26793096; PubMed Central PMCID: PMC4707279.
Sarter, M., Lustig, C., Blakely, R.D., Koshy Cherian, A. Cholinergic genetics of visual state attention: human and mouse choline transporter variants influence distractibility, J. Physiol Paris. 110:10-18, 2016. [PMID: 27404793; PMCID: In Progress]
Ennis, E.A. and Blakely, R.D., Choline on the move: Perspectives on the physiology and pharmacology of the presynaptic choline transporter, Adv Pharmacol 176:175-213, 2016. [PMID: 27288078, PMCID: In Progress]
Bermingham, D.P. and Blakely, R.D., Kinase-dependent regulation of monoamine neurotransmitter transporter regulation, Pharmacological Reviews, 68:888-953, 2016. [PMID: 27591044, PMCID: In Progress]
Brindley, R. L., Bauer, M.B., Blakely, R.D., and Currie, K.P.M. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus secretion coupling in sympathoadrenal chromaffin cells, Neuropharmacology, 110, 438-448, 2016. [PMID: 27544824: PMCID: IN Progress]
Bertron, J.L., Ennis, E.A., Tarr, C.J., Dickerson, J.W., Wright, J., Locuson, C.W., Blobaum, A.L. Rook, J.M., Blakely, R.D., and Lindsley, C.W. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound, Biorg and Med Chem Letters, 4637-4640, 2016. [PMID: 27575469; PMCID:IN Progress].
Robinson, S.B., Hardaway, J.A., Hardie, S.L., Wright, J., Glynn, R.M., Sturgeon, S.M., Freeman, P., Blakely, R.D., Sequence determunants of the C. elegans dopamine transporter dictating in vivo axonal export and synaptic localization, Mol Cell Neurosci, 78:41-51, 2016. [PMID: 27913309; PMCID: In Progress]
Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H, Deneris ES, Hewlett WA, Blakely RD. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Transl Psychiatry. 2015 Nov 3;5:e671. doi: 10.1038/tp.2015.168. PubMed PMID: 26529424.
Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM 3rd, Carvelli L, Hardie SL, Blakely RD. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. J Neurosci. 2015 Jun 24;35(25):9409-23. doi: 10.1523/JNEUROSCI.0800-15.2015 [PMID: 26109664]
Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Genetic Variation in Alpha2-Adrenoreceptors and Heart Rate Recovery after Exercise. Physiol Genomics. 2015 Jun 9:physiolgenomics.00124.2014.doi:10.1152/physiolgenomics.00124.2014 Epub ahead of print. [PMID: 26058836]
Bollinger SR, Engers DW, Ennis EA, Wright J, Locuson CW, Lindsley CW, Blakely RD, Hopkins CR. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1757-60. doi: 10.1016/j.bmcl.2015.02.058. Epub 2015 Feb 28. [PMID: 25801932; PMCID: PMC4385452]
Kovtun O, Sakrikar D, Tomlinson ID, Chang JC, Arzeta-Ferrer X, Blakely RD, Rosenthal SJ. Single-Quantum-Dot Tracking Reveals Altered Membrane Dynamics of an Attention-Defecit/Hyperactivity-Disorder-Derived Dopamine Transporter Coding Variant. ACS Chem Neurosci. 2015 Mar 16. Epub ahead of print. [PMID: 25747272]
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. 3D visualization of the regional differences. Mol Psychiatry. 2015 Feb; 20(1):1 doi: 10.1038/mp.2014.168 [PMID: 25648202]
Chen X, Ye R, Gargus JJ, Blakely RD, Dobrenis K, Sze JY. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01062-6. doi: 10.1016/j.celrep.2014.12.033. Epub ahead of print. [PMID: 25600870]
Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27. doi: 10.1021/cn5001809. Epub 2015 Feb 2. [PMID: 25560927; PMCID: PMC4367188]
Berry AS, Blakely RD, Sarter M, Lustig C. Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics. Neuroimage. 2015 Mar; 108:386-95. doi: 10.1016/j.neuroimage.2014.12.036. Epub 2014 Dec 20. [PMID: 25536497; PubMed in process]
Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior and alters in vivo responses to psychostimulants. Proc Natl Acad Sci USA, 2014 Nov 4;111(44):E4779-88 [PMID: 25331903; PMCID: PMC4226116]
Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJ, Erreger K, Galli A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014 Oct 14;4:e464. doi: 10.1038/tp2014.90. [PMID: 25313507; PubMed - in process].
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Mol Psychiatry. 2014 Sep 9. doi 10.1038/mp.2014.98. Epub ahead of print. [PMID: 25199916; PubMed - as supplied by publisher].
Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 2014 Sep 5;275:184-93. doi: 10.1016/j.neuroscience.2014.06.012. Epub 2014 Jun 17. [PMID: 24950119; PMCID: PMC4122660].
Hardaway JA, Wang J, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. J Neurosci Methods. 2014 May 2:232C:58-62. doi: 10.1016/j.neumeth.2014.04.024 Epub ahead of print [PMID: 24792527; PMCID: PMC4179448].
Blakely RD, Ortega A, Robinson MB. The brain in flux: genetic, physiologic, and therapeutic perspectives on transporters in the CNS. Neurochem Int. 2014 Jul;73:1-3. doi: 10.1016/j.neuint.2014.04.008. Epub 2014 Apr 18. No abstract available. [PMID: 24751395; PubMed - in process].
Berry AS, Demeter E, Sabhapathy S, English BA, Blakely RD, Sarter M, Lustig C. Disposed to Distraction: Genetic Variation in the Cholinergic System Influences Distractibility But Not Time-on-Task Effects. J Cogn Neurosci. 2014 Mar 25. Epub ahead of print [PMID: 24666128; PubMed – in process].
Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J Neurochem, 2014 Jul;130(1):109-14. doi: 10.1111/jnc.12697, Epub 2014 Mar 18 [PMID: 24611756; PMCID: PMC4065617].
Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes Brain Behav. 2014 Mar;13(3):261-75. doi: 10.1111/gbb.12119. Epub 2014 Feb 6 [PMID: 24405699; PubMed – in process].
Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan;466(1):25-42, doi: 10.1007/s00424-013-1410-1. Epub 2013 Dec 13 [PMID: 24337881, PMCID: PMC3930102].
Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: On the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70. doi 10/1016/j.neuint.2013.11.009. Epub 2013 Dec 8 [PMID: 24332984; PMCID: PMC 4177817].
Holmstrand EC, Lund D., Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochem Int. 2014 Jul;73:217-28. doi: 10.1016/j.neuint.2013.11.008. Epub 2013 Nov 22 [PMID: 24274995; PMCID: PMC4104494].
Gowrishankar R, Hahn MK, Blakely RD. Good riddance to dopamine: Roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. Neurochem Int. 2014 Jul;73:42-8. doi: 10.1016/j.neuint.2013.10.016. Epub 2013 Nov 11 [PMID: 24231471; PubMed – in process].
Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav. 2014 Mar;13(3):247-60. doi: 10.1111/gbb.12092. Epub 2013 Oct 31 [PMID: 24102824; PMCID: PMC3979832].
Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem, 2013 Jan 4;288(1):20-32, [PMID: 23161550; PMCID: PMC3537014].
Baganz NL, Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci, 2013 Jan 16;4(1):48-63, [PMID: 23336044; PMCID: PMC3547518].
Parikh V, St. Peters M, Blakely RD, Sarter M. The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. J Neurosci, February 6, 2013, 33(6):2326-2337, [PMID: 23392663; PMCID: PMC3711270].
Paolone G, Mallory CS, Cherian AK, Miller TR, Blakely RD, Sarter M. Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: A model of cholinergic capacity limits.Neuropharmacology, 2013 Aug 16; 75C:274-285, [PMID: 23958450].
Campbell NG, Zhu CB, Lindler KM, Yaspan BL, Kistner-Griffin E; NIH ARRA Consortium, Hewlett WA, Tate CG, Blakely RD, Sutcliffe JS. Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Mol Autism. 2013 Aug 16;4(1)28, [PMID: 23953133].
Kerr TM, Muller CL, Miah M, Jetter CS, Pfeiffer R, Shah C, Baganz N, Anderson GM, Crawley JN, Sutcliffe JS, Blakely RD, Veenstra-Vanderweele J. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice.Mol Autism. 2013 Oct 1; 4(1):35, [PMID: 24083388].
Dong Y, Dani JA, Blakely RD. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels and blunts dopamine elevations following cocaine or nicotine. Biochem Pharmacol. 2013 Oct 15; 86(8):1084-8, [PMID: 23939187].
Engers DW, Bollinger SR, Ennis EA, Wright J, Wu M, Ruggiero AM, McManus OB, Lin Z, Huang X, Blakely RD, Lindsley CW, Li M, Hopkins CR. Discovery and structure-activity relationship of a novel choline transporter inhibitor. MLPCN Probe Report, 2013, Bookshelf ID: pending.
Ruggiero AM, Wright J, Ferguson SM, Lewis M, Emerson KS, Iwamoto H, Ivy MT, Holmstrand EC, Ennis EA, Weaver CD, Blakely RD. Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. ACS Chem Neurosci, 3(10):767-81, 2012. [PMID: 23077721; PMCID: 3474274].
Chang JC, Kovtun O, Blakely RD, Rosenthal SJ. Labeling of neuronal receptors and transporters with quantum dots. WIREs Nanomed Nanobiotechnol, 4(6):605-619. doi: 10.1002/wnan.1186, 2012. [PMID: 22887823; PMCID: 3753009].
Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AMD, Piston DW, Blakely RD, Rosenthal SJ., Single Molecule Analysis of Serotonin Transporter Regulation Using Antagonist-Conjugated Quantum Dots Reveals Restricted, p38 MAPK-Dependent Mobilization Underlying Uptake Activation. J Neurosci, 32(26):8919-8929, 2012 Jun 27, [PMID: 22745492; PMCID: 3426861].
Bonnin A, Zhang L, Blakely RD, Levitt P. The SSRI Citalopram Affects Fetal Thalamic Axon Responsiveness to Netrin-1 In vitro Independently of SERT Antagonism. Neuropsychopharmacology. 37(8): 1879-84, 2012 [PMID: 22414815; PMCID: 3376320].
Sakrikar D, Mazei-Robison MS, Mergy MA, Richtand NW, Han Q, Hamilton PJ, Bowton E, Galli A, Veenstra-Vanderweele J, Gill M, Blakely RD. Attention Deficit/Hyperactivity Disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. J. Neurosci. 32(16):5385-5397, 2012. [PMID: 22514303; PMCID: 3342037].
Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, Cohen J, Mannangatti P, Jessen T, Thompson BJ, Ye R, Kerr TM, Carneiro AM, Crawley JN, Sanders-Bush E, McMahon DG, Ramamoorthy S, Daws LC, Sutcliffe JS, Blakely RD. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. PNAS. 109(14):5469-5474, 2012. [PMID: 22431635; PMCID: 3325657].
Blakely RD, Edwards RH. Vesicular and Plasma Membrane Transporters for Neurotransmitters. Cold Spring Harb. Perspect. Biol. 2012; 4:a005595. [PMID: 22199021].
Gilbert J, Haman KL, Dietrich MS, Blakely RD, Shelton RC, Murphy BA. Depression in patients with head and neck cancer and a functional genetic polymorphism of the serotonin transporter gene. Head Neck. 34(3):359-364, 2012. [PMID: 21604315, PMCID: in process].
Veenstra-VanderWeele J, Blakely RD. Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments. Neuropsychopharmacology. 37(1):196-212, 2012. [PMID: 21937981; PMCID: 3238072].
Hardaway JA, Hardie SL, Whitaker SM, Baas SR, Zhang B, Bermingham DP, Lichtenstein AJ, Blakely RD. Forward Genetic Analysis to Identify Determinants of Dopamine Signaling in Caenorhabditis elegans Using Swimming Induced Paralysis. G3, 2(8), August 2012, [PMID: 22908044; PMCID: 3411251].
Zurkovsky L, Bychkov E, Tsakem EL, Siedlecki C, Blakely RD, Gurevich EV. Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity. Dis Model Mech, ePub ahead of print, 2012 Aug 3, [PMID: 22864020; PMCID: 3529349].
Tomlinson ID, Iwamoto H, Blakely RD, Rosenthal SJ. Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT). Bioorg Med Chem Lett. 2011 Mar 15; 21(6):1678-82; [PMID: 21334895; PMCID: 3070488].
Thompson BJ, Jessen T, Henry LK, Field JR, Gamble KL, Gresch PJ, Carneiro AM, Horton RE, Chisnell PJ, Belova Y, McMahon DG, Daws LC, Blakely RD. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proc Natl Acad Sci U S A. 2011 Mar 1; 108(9):3785-90; [PMID: 21282638; PMCID: 3048100].
Rasul A, El-Nour H, Blakely RD, Lonne-Rahm SB, Forsberg J, Johansson B, Theodorsson E, Nordlind K. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Arch Dermatol Res. 2011 Nov; 303(9):625-33. doi: 10.1007/s00403-011-1138-8. Epub 2011 Mar 15; [PMID: 21400247].
Kohli U, Hahn MK, English BA, Sofowora GG, Muszkat M, Li C, Blakely RD, Stein CM, Kurnik D. Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.Pharmacogenet Genomics. 2011 Apr; 21(4):171-8; [PMID: 21412203; PMCID: 3065933]
Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21; 472(7343):347-50; [PMID: 21512572; PMCID: 3084180].
Kovtun O, Tomlinson ID, Sakrikar DS, Chang JC, Blakely RD, Rosenthal SJ. Visualization of the cocaine-sensitive dopamine transporter with ligand-conjugated quantum dots. ACS Chem Neurosci. 2011 Jul 20; 2(7):370-8. Epub 2011 Apr 26. [PMID: 22816024; PMCID: 3369746].
Blakely RD, Veenstra-VanderWeele J. Genetic indeterminism, the 5-HTTLPR, and the paths forward in neuropsychiatric genetics. Arch Gen Psychiatry. 2011 May; 68(5):457-8; [PMID: 21536974; PMCID: 3686479].
Zhu CB, Lindler KM, Campbell NG, Sutcliffe JS, Hewlett WA, Blakely RD. Colocalization and regulated physical association of presynaptic serotonin transporters with A3 adenosine receptors. Mol Pharmacol. 2011 Sep; 80(3):458-65. Epub 2011 Jun 24; [PMID: 21705486; PMCID: 3164334].
Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, Meiler J, Blakely RD. A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. J Biol Chem. 2011 Sep 2; 286(35):30823-36. Epub 2011 Jul 5. [PMID: 21730057; PMCID: 3162443].
Ye R, Blakely RD. Natural and engineered coding variation in antidepressant-sensitive serotonin transporters.Neuroscience. 2011 Dec 1;197:28-36. Epub 2011 Aug 28; [PMID: 21893166, PMCID: 3850749].
Erickson SL, Gandhi AR, Asafu-Adjei JK, Sampson AR, Miner L, Blakely RD, Sesack SR. Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex. Int J Neuropsychopharmacol. 2011 Oct; 14(9):1219-32. Epub 2011 Jan 6; [PMID: 21208501; PMCID: 3117082].
Chang JC, Tomlinson ID, Warnement MR, Iwamoto H, DeFelice LJ, Blakely RD, Rosenthal SJ. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. J Am Chem Soc. 2011 Nov 9; 133(44):17528-31. Epub 2011 Oct 17; [PMID: 21970724; PMCID: 3235909].
Combs S, Kaufmann K, Field JR, Blakely RD, Meiler J. Y95 and e444 interaction required for high-affinity s-citalopram binding in the human serotonin transporter. ACS Chem Neurosci. 2011 Feb 16; 2(2):75-81. Epub 2010 Oct 27; [PMID: 22778858; PMCID: 3369724].