Dr. Iragavarapu-Charyulu's Research
For the past 20 years, Dr. Vijaya Iragavarapu-Charyulu has been studying the role of tumor-derived and tumor-induced factors that play a role in breast cancer progression.
The focus of her research is to determine the mechanisms involved in accelerated metastasis of breast cancer. She has been studying the influence of comorbidities such as allergen pulmonary inflammation with breast cancer. Her broad background in tumor immunology, tumor biology and molecular cell biology and other key research areas enable her to successfully conduct this research. Her expertise is in inflammatory mediators that include CHI3L1, cytokines, chemokines & MMPs and how these molecules play crucial roles in tumor growth, angiogenesis and metastasis. Her recent area of interest is in assessing the role of CHI3L1 in inflammation associated with pulmonary allergic inflammation and tumor-associated inflammation. Her initial work with CHI3L1 laid the foundation to delineate the synergistic effect of pulmonary and tumor-associated inflammation in contributing to tumor growth and metastasis. As a research associate at University of Miami, she previously studied how tumor-derived factors affect cytokine production by lymphocytes leading to understanding the role cachexia in tumor bearers. Since joining Charles E. Schmidt College of Medicine, she has shifted her focus to the role of inflammation in accelerating breast cancer metastasis. She has been continuously funded by Florida Department of Health and NIH/NCI.