Janet D. Robishaw, Ph.D.
Janet D. Robishaw received her B.S. degree from Central Michigan University with a Double Major in Chemistry and Biology followed by a Ph.D. in Physiology from Pennsylvania State University College of Medicine. Her doctoral research focused on characterizing the biochemical mechanisms underlying cardiac energy metabolism. Her postdoctoral training was conducted in the laboratory of Dr. Alfred G. Gilman at the Southwestern Medical School, University of Texas Health Sciences Center. Dr. Robishaw’s post-doctoral research revolved around the structure, function and first molecular cloning of the newly discovered the heterotrimeric G-proteins. Her work contributed to the discovery of heterotrimeric G-proteins and their roles in signal transduction for which Dr. Gilman’s team was awarded the 1994 Nobel Prize in Physiology and Medicine. While attaining the rank of Full Professor at Pennsylvania State University College of Medicine and Associate Director of Translational Research at Geisinger Health System, her research utilized a broad range of molecular, biochemical, physiological, and genetic approaches to decipher how structural heterogeneity of the heterotrimeric G-proteins mediates such diverse functions as cardiovascular and cognitive performance. More recently, her work has delved into understanding their roles in various diseases processes. Altogether, Dr. Robishaw's research has been continuously supported for >30 years by the National Institutes of Health and the results have appeared in >100 peer-reviewed papers, reviews, and book chapters. Among multiple honors, she has been named an Established Investigator of the American Heart Association.In 2016, Dr. Robishaw moved to Florida Atlantic University as Professor and Chair of Biomedical Science of the Charles E. Schmidt College of Medicine, and later, assumed an additional role as the Senior Associate Dean of Research for the college. The current focus of her own research program is the identification of human disease-associated genetic variants. The multi-disciplinary approach utilizes genomic analysis of large patient cohorts to identify potential disease variants followed by assessment of their disease-causing mechanisms in relevant human cellular and animal models. To provide the greatest clinical impact, the major emphasis focuses on G-protein mediated signaling pathways since they represent the most “druggable” targets for disease treatments. The results of this research will add to the growing knowledge base that is needed for “personalized” medicine to become a reality for the vast majority of patients. Through recruitment and establishment of strategic collaborations, Dr. Robishaw’s vision is for the Charles E. Schmidt College of Medicine to become a learning healthcare center that relies on continuing research to advance the education, dissemination, and practice of medicine.In addition to her long-standing commitment to research, Dr. Robishaw is dedicated to education and training. She led the medical research education program at Geisinger Health System for >20 years, and in the process, developed a highly competitive summer undergraduate research program. Of the nearly 150 trainees, the vast majority of them pursued post-graduate training in the health professions. She has also trained numerous Masters, Ph.D., M.D. students, and post-doctoral fellows. Finally, she has implemented multiple initiatives for K-12 students to explore science in fun and empowering ways, and to relate the importance of science for solving healthcare problems of the surrounding communities.
- 1979: B.S., Chemistry and Biology, Central Michigan University, Mt. Pleasant, MI
- 1983: Ph.D., Physiology, Pennsylvania State University, College of Medicine, Hershey, PA
- 1987: Post-Doctoral Fellow, University of Texas Health Center, Southwestern Medical School, Dallas, TX
- 2017-Present: Senior Associate Dean for Research, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
- 2016-Present: Chair of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
- 2016-Present: Professor of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL
- 2005-2016: Associate Director, Geisinger Health System, Weis Center for Research, Danville, PA
- 2004-2016: President and CEO, SignalPlex, Danville, PA
- 2000-2016: Senior Scientist, Geisinger health System, Weis Center for Research, Danville, PA
- 2000-2016: Director of Research Education, Geisinger Clinic, Weis Center for research, Danville PA
- 1997-2000: Professor with tenure, Department of Molecular and Cellular Physiology, Pennsylvania State University, Hershey, PA
- 1996-1997: Senior Scientist, Geisinger Health Clinic, Weis Center for Research, Danville, PA
- 1987-1996: Staff Scientist, Geisinger Health Clinic, Weis Center for Research, Danville, PA
- 1983-1987: Post-doctoral Fellow and Research Assistant Professor Supervisor, Dr. Alfred G. Gilman, Nobel Laureate (1994 Nobel Prize in Physiology and Medicine) University of Texas Health Sciences Center, Southwestern Medical School Dallas, TX
Selected Peer-Reviewed Publications
- Schwindinger WF, Sheridan K, Boscarino J, Erlich P, Gerhard G, and Robishaw JD. The G-protein γ7 is a likely genetic contributor to opioid actions in humans and mice, In preparation.
- Chen H, Leung TC, Humbert J, Stauffer A, Sinha S, Giger K, Hansen CA, and Robishaw JD. Critical role for the zebrafish G protein γT1 subunit in melatonin production, In preparation.
- Mi W, Lin Q, Childress C, Sudol M, Robishaw JD, Berlot CH, Shabahang M, Yang W. Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration. Oncogene. 2014 Aug 11. doi: 10.1038/onc.2014.251. [Epub ahead of print]
- Moon AM, Stauffer AM, Schwindinger WF, Sheridan K, Firment A, Robishaw JD. Disruption of G-protein γ5 PLoS One, 9(3): e90970, 2014. subtype causes embryonic lethality in mice.
- Robishaw JD. Preferential assembly of G-proteins by the γ subunits. Subcell Biochem. 63: 181-91, 2012.
- Schwindinger WF, Mirsahi U, Baylor KA, Sheridan KM, Stauffer AM, Usefof S, Stecker MM, Mirshahi T, Robishaw JD. Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knockout mice. J Biol. Chem. 287(10):7121-33, 2012.
- 1983-1986 National Research Service Award, National Institute of Health
- 1988 Selected Speaker, Science Writer's Forum, American Heart Association
- 1988-89 Regular Member of Biochemistry Study Section, National American Cancer Society
- 1989 Member of Research Review Group, Pennsylvania Affiliate of the American Heart Association
- 1990 Member of SCOR Review Committee, National Institutes of Health
- 1989-1994 Established Investigator Award, National American Heart Association
- 1990 Delegate for National Institutes of Health US-USSR Symposium on “Cardiovascular and Pulmonary Biology”, Suzdal, USSR
- 1991-1995 Regular Member of Pharmacology Study Section, National Institutes of Health
- 1993 Advisory Panel Member, “Future Directions in Neuroscience Research”, National Institutes of Health
- 1993-1998 Editorial Board Member, Journal of Biological Chemistry
- 1996 Chairperson for ASPET Symposium on "Role of βγ subunits in G protein- mediated signaling”, Experimental Biology '96 Meeting.
- 1996-2000 Regular Member and Co-Chair of the Molecular Signaling I Study Section, National American Heart Association
- 1999-2002 Regular Member, Pharmacology Study Section, National Institutes of Health 2002-2005 Executive Committee Member, Cardiovascular Division, American Society of Pharmacology and Therapeutics
- 2009 Reviewer, Glue Grant, National Institutes of Health
- 2007-2012 Regular Member of Molecular and Integrative Signal Transduction, National Institutes of Health
- 2013 Ad hoc Member, Vascular Biology, National Institutes of Health
- American Society for Biochemistry and Molecular Biology
- American Association for Advancement of Science
- International Society for Heart Research
- American Society for Pharmacology and Experimental Therapeutics
- International Academy of Cardiovascular Sciences
- Society for Developmental Biology
5R01GM114665-04PI: J Robishaw
NOVEL ASPECTS OF GOLF SIGNALING
Project Period: 2015-2019
5R01GM111913-03 Multi PI: J Robishaw
AN INTEGRATED APPROACH TO STUDY GPCR VARIANTS ASSOCIATED WITH COMPLEX DISEASES
Project Period: 2015-2019
5R01HL134015-02Multi PI: J Robishaw
APPROACHES TO GENETIC HETEROGENEITY OF OBSTRUCTIVE SLEEP APNEA
Project Period: 2016-2020
1R01DA044015-01A1Multi PI: Robishaw
CLINICAL AND GENETIC STUDY OF PRESCRIPTION OPIOID ADDICTION
Project Period: 2017-2022