2018 Publications

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.. Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, Watterson DM, Blakely RD. Proc Natl Acad Sci U S A. 2018 Oct 8. pii: 201809137. doi: 10.1073/pnas.1809137115. [Epub ahead of print] PMID: 30297392

Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM. Pharmacol Res. 2018 Jun 9. pii: S1043-6618(18)30429-8. doi: 10.1016/j.phrs.2018.06.008. [Epub ahead of print] PMID: 29894763

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation. Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ. Mol Metab. 2018 Jun 6. pii: S2212-8778(18)30304-1. doi: 10.1016/j.molmet.2018.06.003. [Epub ahead of print]

Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1. Gibson CL, Codreanu SG, Schrimpe-Rutledge AC, Retzlaff CL, Wright J, Mortlock DP, Sherrod SD, McLean JA, Blakely RD. Mol Omics. 2018 Jun 12;14(3):142-155. doi: 10.1039/c7mo00022g. PMID: 29868674

Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone. Refai O, Blakely RD. Neurochem Int. 2018 May 22. pii: S0197-0186(18)30169-4. doi: 10.1016/j.neuint.2018.05.013. [Epub ahead of print] PMID: 29800604

Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559. Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD. J Neurosci. 2018 Jun 6;38(23):5302-5312. doi: 10.1523/JNEUROSCI.0055-18.2018. Epub 2018 May 8. PMID: 29739866

Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging. Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP. Mol Autism. 2018 Apr 10;9:24. doi: 10.1186/s13229-018-0210-z. eCollection 2018. PMID: 29651330

Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Gibson CL, Balbona JT, Niedzwiecki A, Rodriguez P, Nguyen KCQ, Hall DH, Blakely RD. PLoS Genet. 2018 Mar 28;14(3):e1007269. doi: 10.1371/journal.pgen.1007269. eCollection 2018 Mar. PMID: 29590100

Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, Chioza BA, Blakely RD, Chilton JK, De Bleecker J, Baets J, Baple EL, Walk D, Crosby AH. Neurol Genet. 2018 Mar 23;4(2):e222. doi: 10.1212/NXG.0000000000000222. eCollection 2018 Apr. PMID: 29582019

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA. Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. Erratum in: Cell Rep. 2018 Jul 24;24(4):1081-1084. PMID: 29298426

Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. Dai H, Jackson CR, Davis GL, Blakely RD, McMahon DG. J Neurodev Disord. 2017 Dec 28;9(1):38. doi: 10.1186/s11689-017-9215-8. PMID: 29281965

Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, Sejersen T, Wright J, Zimmerman HH, Karakaya M, Stüve B, Weis J, Schara U, Russell MA, Abdul-Rahman OA, Chilton J, Blakely RD, Baple EL, Cirak S, Crosby AH. Brain. 2017 Nov 1;140(11):2838-2850. doi: 10.1093/brain/awx249. PMID: 29088354

Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD. Behav Brain Res. 2018 Jan 30;337:61-69. doi: 10.1016/j.bbr.2017.09.043. Epub 2017 Sep 28. PMID: 28964912

Spatial gene expression analysis of neuroanatomical differences in mouse models. Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Neuroimage. 2017 Dec;163:220-230. doi: 10.1016/j.neuroimage.2017.08.065. Epub 2017 Sep 4. PMID: 28882630

The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism. Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM 3rd, Blakely RD. J Neurosci. 2017 Sep 20;37(38):9288-9304. doi: 10.1523/JNEUROSCI.1582-17.2017. Epub 2017 Aug 21. PMID: 28842414

Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. Retzlaff CL, Kussrow A, Schorkopf T, Saetear P, Bornhop DJ, Hardaway JA, Sturgeon SM, Wright J, Blakely RD. ACS Chem Neurosci. 2017 Oct 18;8(10):2132-2138. doi: 10.1021/acschemneuro.7b00232. Epub 2017 Aug 14. PMID: 28783953

Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity. Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M. Neurochem Int. 2017 Sep;108:410-416. doi: 10.1016/j.neuint.2017.05.022. Epub 2017 May 31. PMID: 28577989

Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response. Brindley RL, Bauer MB, Blakely RD, Currie KPM. ACS Chem Neurosci. 2017 May 17;8(5):943-954. doi: 10.1021/acschemneuro.7b00026. Epub 2017 Apr 13. Review. PMID: 28406285

Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. Robson MJ, Quinlan MA, Blakely RD. ACS Chem Neurosci. 2017 May 17;8(5):932-942. doi: 10.1021/acschemneuro.6b00412. Epub 2017 Apr 3. Review. PMID: 28345868

An autism-associated serotonin transporter variant disrupts multisensory processing. Siemann JK, Muller CL, Forsberg CG, Blakely RD, Veenstra-VanderWeele J, Wallace MT. Transl Psychiatry. 2017 Mar 21;7(3):e1067. doi: 10.1038/tp.2017.17. PMID: 28323282

Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M. J Neurosci. 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13. PMID: 28193693

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Bermingham DP, Blakely RD. Pharmacol Rev. 2016 Oct;68(4):888-953. doi: 10.1124/pr.115.012260. Review. PMID: 27591044

Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bertron JL, Ennis EA, Tarr CJ, Wright J, Dickerson JW, Locuson CW, Blobaum AL, Rook JM, Blakely RD, Lindsley CW. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-4640. doi: 10.1016/j.bmcl.2016.08.062. Epub 2016 Aug 21. PMID: 27575469

Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility. Sarter M, Lustig C, Blakely RD, Koshy Cherian A. J Physiol Paris. 2016 Sep;110(1-2):10-18. doi: 10.1016/j.jphysparis.2016.07.001. Epub 2016 Jul 9. Review. PMID: 27404793