Peripheral Inflammation Limits Serotonin Neuron Signaling Capacity via Serotonergic IL-1R1 to Reduce Neuronal Excitability and Enhance Serotonin Clearance
P. A. Gajewski, H. Iwamoto, A. N. Tillman, Z. Filliben, A. E. Walsh, N. L. Baganz, M. J. Robson, M. Zapata, N.Quan, R. D. Blakely
bioRxiv 2025.10.13.682078; doi: https://doi.org/10.1101/2025.10.13.682078


The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction
Stewart A, Blakely RD
Adv Neurobiol. 2025;46:235-270. doi: 10.1007/978-3-031-96364-3_10.
PMID: 41051713


Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant.
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S.
Mol Psychiatry. 2025 May 29. doi: 10.1038/s41380-025-03055-4. Online ahead of print.
PMID: 40442453


Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis.
Rodriguez P, Kalia V, Fenollar-Ferrer C, Gibson CL, Gichi Z, Rajoo A, Matier CD, Pezacki AT, Xiao T, Carvelli L, Chang CJ, Miller GW, Khamoui AV, Boerner J, Blakely RD.
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2320611121. doi: 10.1073/pnas.2320611121. Epub 2024 Sep 17.
PMID: 39288174


Forward genetic screen of the C. elegans million mutation library reveals essential, cell-autonomous contributions of BBSome proteins to dopamine signaling.
Refai O, Rodriguez P, Gichi Z, Blakely RD.
J Neurochem. 2024 Sep;168(9):2073-2091. doi: 10.1111/jnc.16188. Epub 2024 Aug 8.
PMID: 39118406