Drug-NT Interactions

• Acetylcholine (ACh) release is blocked by botulinum toxin

• ACh release is promoted by black widow spider venom

• Cocaine blocks the reuptake of dopamine

• LSD stimulates serotonin receptors

• Natural lipid of THC (active ingredient in marijuana) interferes with 5-HT (serotonin) receptors

• Caffeine blocks adenosine receptors

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Curare (indian hunting darts) blocks ACh?paralysis

Improperly canned food can have a poison (botulin) that causes paralysis by blocking acetylcholine release

Venom of black widow spider results in flood of ACh?muscle contractions/convulsions and/or death.

Cocaine, DA agonist, used as a topical anesthetic such as in eye drops prior to eye surgery.

LSD produces visual distortions (hallucinogenic effects)

5-HT3 receptors have role in preventing vomiting: THC useful in treating side-effects of chemotherapy and radiation

Caffeine produces excitatory effects by blocking adenosine (a neuromodulator in the brain)

(Video)