Slide 9 of 24
Notes:
Drugs that activate PREsynaptic receptors=antagonists (b/c this causes the autoreceptors to release LESS NT) and vice-versa.
A drug that activates POSTsynaptic receptors=agonist and vice-versa
Presynaptic autoreceptors regulate the amount of NT released from the axon terminal
Drugs that activate presynaptic autoreceptors reduce the amount of NT released, an antagonistic action
Drugs that inactivate presynaptic autoreceptors increase the amount of NT released, an agonistic action
Presynaptic heteroreceptors are sensitive to NT released by another neuron
The effect of activating or inhibiting a HETEROreceptor depends on whether the heteroreceptor is responsible for presynaptic facilitation or inhibition.
1st step: synthesis of NT from precursors, which is controlled by enzymes
More important here to note that there are agonists (AGO) and antagonists (ANT) and see some examples of AGO and ANT for each of the neurotransmitters.
