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REGULATED CELL DEATH SIGNALING PATHWAYS AND MARINE NATURAL PRODUCTS THAT TARGET THEM  

Natural Products

BY LYNDA F. RYSAVY | MARCH 25, 2019

Florida Atlantic University’s Harbor Branch Oceanographic Institute researchers are trying to fully understand how marine natural products can be used to target and kill cancer cells and how that process works. 

Esther Guzmán, Ph.D., associate research professor at FAU Harbor Branch served as guest editor of a special issue of Marine Drugs that addresses the “Connection of Marine Natural Products and Cell Apoptosis," or cell death.

Her article titled, "Regulated Cell Death Signaling Pathways and Marine Natural Products That Target Them," offers a review of our current understanding of the signaling pathways regulating cell death, and highlights marine natural products that can affect these signaling pathways.

The special issue focuses on marine natural products that act upon apoptosis in all its forms: promoting it, regulating it, and preventing it.

As our understanding of the molecular process of apoptosis continues to grow, marine natural products that act upon this pathway have increased relevance, as they not only have therapeutic potential but also may help us further our understanding of the complex processes of cell death and how cell fate is determined.

Research Excellence funds from the Harbor Branch Oceanographic Institute Foundation awarded to Dr. Guzmán made this publication possible.