<p>Dr. Shirley Pomponi is Executive Director Cooperative Institute Ocean Exploration Research and Technology of Harbor Branch Oceanographic Institute at Florida Atlantic University. She received her Ph.D. in Biological Oceanography from the University of Miami, was on the research faculty of the University of Maryland, and joined Harbor Branch in 1984. Her research focuses on marine biotechnology, in general, and sponge cell culture, in particular. She has authored or co-authored more than 90 scientific publications and is co-inventor on several patents. She has led numerous research expeditions worldwide and has made more than 300 dives in Harbor Branch’s Johnson-Sea-Link submersibles. She chairs the National Research Council's Ocean Studies Board and the Consortium for Ocean Leadership, and is President-elect of the Southern Association of Marine Laboratories. She is a member of the Florida Oceans and Coastal Council, the Ocean Research and Resources Advisory Panel, the U.S. National Committee for the Census of Marine Life, the National Association of Marine Laboratories, the Board of Trustees of Midwest Research Institute, and the Board of Trustees of the Women Divers Hall of Fame.</p>
<h3>Education</h3>
<p>College of St. Elizabeth<br /> Biology (summa cum laude)<br /> 1967-1971<br />B.A.</p>
<p>University of Miami, RSMAS<br /> Biological Oceanography<br /> 1971-1974<br /> M.S.</p>
<p>University of Miami, RSMAS<br /> Biological Oceanography<br /> 1975-1977<br /> Ph.D.</p>
<p>University of Miami, RSMAS<br /> Biological Oceanography<br /> 1978-1979<br /> Post-doctoral</p>
<h3>Synergistic Activities</h3>
<ul>
<li>2005-2008 Member, Florida Oceans and Coastal Council</li>
<li>2005-2009 Member, Ocean Research Advisory Panel</li>
<li>2005-2008 Chair, National Academy of Science (NAS) Ocean Studies Board</li>
<li>2003-2005 Member, National Academy of Science (NAS) Ocean Studies Board</li>
<li>2004-2005 Delegate, Scientific Committee on Oceanic Research</li>
<li>2003 Member, NAS Committe on Future Needs in Deep Submergence Science</li>
<li>2003-2006 Member, U.S. National Steering Committee, Census of Marine Life</li>
<li>2003-present Florida Ocean Alliance, Executive Committee</li>
<li>2002-present Member, Board of Governors & Executive Committee, Consortium for Oceanographic Research & Education (CORE)</li>
<li>2002-2004 Member, Science Advisory Panel, U.S. Commission on Ocean Policy</li>
<li>2001-2003 Vice Chair, NAS Committee on Exploration of the Seas</li>
<li>2001-2002 Member, NAS Committee on Marine Biotechnology</li>
<li>2000 Member, President’s Panel on Ocean Exploration</li>
<li>1998-1999 Member, NAS Committee on the Ocean’s Role in Human Health</li>
</ul>
<h3>Recent Honors</h3>
<ul>
<li>2008 Champion of the Ocean, awarded by Monmouth University’s Urban Coast Institute, to honor significant contributions to creating a sustainable ocean environment</li>
<li>2006 Fellow Award, Society for In Vitro Biology in recognition of outstanding professional accomplishments and service to the Society in the area of Animal Cell Sciences</li>
<li>2006 Inducted into Iron Arrow Honor Society, the highest honor attained at the University of Miami</li>
<li>2004 Society for In Vitro Biology, Senior Investigator Award for excellence in research, contributions and achievements in the field of Marine and Comparative Biology</li>
<li>2003 Member, Women Diver’s Hall of Fame</li>
</ul>
<h3>Publications</h3>
<h4>Cell and Molecular Biology</h4>
<p>Conejo, M., Bertin, M., Pomponi, S.A., and Ellington, W.R., 2008. The early evolution of the phosphagen kinases – insights from choanoflagellate and poriferan arginine kinases. <em>Journal of Molecular Evolution</em>, 66(1): 11-20<br /></p>
<p>Pomponi, S.A. 2006. Biology of the Porifera: cell culture. <em>Canadian Journal of Zoology: Special Series on Porifera</em>. 84: 167-174..<br /></p>
<p>Lopez, Jose V., Cheryl L. Peterson, Robin Willoughby, Amy E. Wright, Edward Enright, Stacy Zoladz, and Shirley A. Pomponi. 2002. Characterization of genetic markers for <em>in vitro</em> cell line identification of the marine sponge, <em>Axinella corrugata</em>. <em>Journal of Heredity</em> 93(1): 27-36.<br /></p>
<p>Pomponi, Shirley A. and Robin Willoughby. 2000. Development of sponge cell cultures for biomedical applications. IN: <em>Aquatic Invertebrate Cell Culture</em> (Austin, B. and Mothersill, C., eds), Springer-Praxis New York, N.Y. pp. 323-336.<br /></p>
<p>Willoughby, Robin and Shirley A. Pomponi. 2000. Quantitative assessment of marine sponge cells <em>in vitro</em>: development of improved growth medium. <em>In Vitro Cellular & Developmental Biology</em>, 36:194-200.<br /></p>
<p>Andrade, Paul, Robin Willoughby, Shirley A. Pomponi, and Russel G. Kerr. 1999. Biosynthetic studies of the alkaloid, stevensine, in a cell culture of the marine sponge <em>Teichaxinella morchella</em>. <em>Tetrahedron Letters</em> 40:4775-4778.<br /></p>
<p>Pomponi, Shirley A., Robin Willoughby, Amy E. Wright, Claudia Pecorella, Susan H. Sennett, Jose Lopez, and Gail Samples. 1998. In vitro production of marine-derived antitumor compounds. IN: <em>New Developments in Marine Biotechnology</em> (Y. Le Gal and H. O. Halvorson, eds.), Plenum Press, New York, pp. 73-76.<br /></p>
<p>Pomponi, Shirley A., Robin Willoughby and Michelle Kelly-Borges. 1998. Sponge cell culture. IN: <em>Molecular Approaches to the Study of the Ocean</em> (Cooksey, K.E., ed), Chapman & Hall, Ltd. Publishers in Science, Technology, Medicine and Business, Andover, Hampshire, England, pp. 423-433.<br /></p>
<p>Pomponi, Shirley A., Robin Willoughby, M. Edward Kaighn, and Amy E. Wright. 1997. Development of techniques for in vitro production of bioactive natural products from marine sponges. IN: <em>Invertebrate Cell Culture: Novel Directions and Biotechnology Applications</em>, (Karl Maramorosch and Jun Mitsuhashi, eds.), pp. 231-237.<br /></p>
<p>Yentsch, Clarice M. and Shirley A. Pomponi. 1994. Strategies for flow cytometric analysis of marine microalgae and sponge cells. IN: <em>Methods in Cell Biology</em>. Volume 42: Flow Cytometry. 2nd ed. San Diego, CA, Academic Press. pp. 523-538.<br /></p>
<p>Pomponi, Shirley and Robin Willoughby. 1994. Sponge cell culture for production of bioactive metabolites. IN. <em>Sponges in Time and Space; Biology, Chemistry, Paleontology</em>. Proceedings of the Fourth International Porifera Congress. Editors: Soest, R.W.M van et al. Rotterdam, Netherlands, A.A. Balkema, c1994. pp. 395-400.<br /></p>
<p>Pomponi, Shirley A. and Terry L. Cucci. 1989. Separation and concentration of phytoplankton populations using centrifugal elutriation. <em>Cytometry</em> 10: 580-586.<br /></p>
<p>Pomponi, Shirley A. 1986. Automated individual cell analysis in aquatic research. <em>Int. Rev. Cytol.</em> 105: 183-243.<br /></p>
<p>Pomponi, Shirley A. 1980. Cytological mechanisms of calcium carbonate excavation by boring sponges. <em>Int. Rev. Cytol.</em> 65: 301-319.<br /></p>
<p>Pomponi, Shirley A. 1979. Ultrastructure and cytochemistry of the etching area of boring sponges. <em>Colloq. Int. C.N.R.S</em>., 291: 319-323.<br /></p>
<p>Pomponi, Shirley A. 1979. Excavation of calcium carbonate substrates by boring sponges. I. Ultrastructure of cell types with particular reference to the etching area. <em>J. mar. biol. Ass. U.K.,</em> 59: 777-784.<br /></p>
<p>Pomponi, Shirley A. 1979. Excavation of calcium carbonate substrates by boring sponges. II. Cytochemical investigations of acid phosphatase. <em>J. mar. biol. Ass. U.K</em>., 59: 785-789.<br /></p>
<p>Pomponi, Shirley A. 1977. Etching cells of boring sponges: an ultrastructural analysis. In: D.L. Taylor, ed. <em>Proc., Third Int. Coral Reef Symp</em>., Miami, Vol 2., Geology, pp. 485-490.<br /></p>
<p>Pomponi, Shirley A. 1976. An ultrastructural study of boring sponge cells and excavated substrata. In: O. Johari, ed. <em>Proc. 9</em><sup><em>th</em></sup><em>Ann. SEM Symp</em>., IIT Res. Inst., Chicago, Part VIII, pp. 569-575.<br /></p>
<p>Pomponi, Shirley A. 1976. A cytological study of the Haliclonidae and the Callyspongiidae (Porifera, Demospongiae, Haplosclerida). In: R.W. Harrison & R.R. Cowden, eds. <em>Aspects of Sponge Biology</em>, Academic Press, NY, pp. 215-235.<br /></p>
<h4>Biodiversity<br /></h4>
<p>Reed, J.K., D. Weaver and S.A. Pomponi (In press). Habitat and fauna of deep-water <em>Lophelia pertusa</em> coral reefs off the Southeastern USA. <em>Bulletin of Marine Science.</em><br /></p>
<p>Reed, John K., Shirley A. Pomponi, Doug Weaver, Charles K. Paull and Amy E. Wright. 2005. Deep-water sinkholes and bioherms of south Florida and the Pourtales Terrace – habitat and fauna. <em>Bulletin of Marine Science</em> 77(2): 267-296.<br /></p>
<p>Reed, J.K., A. Wright, S.A. Pomponi. 2004. Medicines from the deep sea: Exploration of the Northeastern Gulf of Mexico. IN: <em>Proceedings of the American Academy of Underwater Sciences 23</em><sup><em>rd</em></sup><em>Annual Scientific Diving Symposium</em>, March 11-13, 2004 pp. 58-70.<br /></p>
<p>Reed, John K., Susan H. Sennett, Peter J. McCarthy, Tara A. Pitts, Amy E. Wright, and Shirley A. Pomponi. 1998. Bioactivity of marine organisms: relationships with taxonomy, geography and depth. IN: <em>Proceedings of the American Academy of Underwater Sciences 18</em><sup><em>th</em></sup><em>Annual Symposium</em>, Vancouver, British Columbia, October 8-11, 1998.<br /></p>
<p>Reed, John K. and Shirley A. Pomponi. 1997. Biodiversity and distribution of deep and shallow water sponges in the Bahamas. <em>Proceedings of the Eighth International Coral Reef Symposium</em> 2: 1387-1392.<br /></p>
<p>Pomponi, Shirley A., John K. Reed, Amy E. Wright, Peter J. McCarthy. 1996. Diversity and Bioactivity of Marine Sponges of the Caribbean: The Turks and Caicos Islands. <em>Caribbean Journal of Agriculture and Natural Resources</em> (CAJANAR). 1(1):41-49.<br /></p>
<p>Reed, John K. and Shirley A. Pomponi. 1992. Submersible and scuba collections for bioactive organisms from the Azores to western Africa. IN:<em>International Pacific Scientific Diving</em>. 1991; 11th Annual Scientific Diving Symposium. Costa Mesa, CA, American Academy of Underwater Sciences, c1992. pp. 65-74.<br /></p>
<h4>Systematics<br /></h4>
<p>Sfanos, Karen, Dedra Harmody, Phat Dang, Angela Ledger, Shirley Pomponi, Peter McCarthy and Jose Lopez. 2005. A molecular systematic survey of cultured microbial associates of deep water marine invertebrates. <em>Systematic and Applied Microbiology</em> 28: 242-264.<br /></p>
<p>Gunasekera, Aravinda S., Karen S. Sfanos, Dedra K. Harmody, Shirley A. Pomponi, Peter J. McCarthy and Jose P. Lopez. 2005. HBMMD: an enhanced database of the microorganisms associated with deeper water marine invertebrates. <em>Applied Microbiology and Biotechnology</em> 66: 373-376.<br /></p>
<p>Sandell, Karen, Cheryl Peterson, Dedra Harmody, Peter J. McCarthy, Shirley A. Pomponi and Jose V. Lopez. 2004. A molecular systematic survey of sponge derived microbes. <em>Bollettino dei Musei e Degli Istituti Biologici dell’Universita di</em> Genova 68: 579-585.<br /></p>
<p>Thiel, Volker, Martin Blumenberg, Jens Hefter, Thomas Pape, Shirley Pomponi, John Reed, Joachim Reitner, Gert Worheide and Walter Michaelis. 2002. A chemical view of the most ancient metazoa – biomarker chemotaxonomy of hexactinellid sponges. <em>Naturwissenschaften</em> 89: 60-66.<br /></p>
<p>Pomponi, Shirley A., Michelle Kelly, John K. Reed and Amy E. Wright. 2001. Diversity and bathymetric distribution of lithistid sponges in the tropical western Atlantic region. <em>Proceedings of the Biological Society of Washington</em> 10: 344-353.<br /></p>
<p>Maldonado, M., Shirley A. Pomponi, M. Carmen Carmona. 2001. First record of the sponge genera <em>Crambe</em> and <em>Discorhabdella</em> for the eastern Pacific, with description of three new species. <em>Journal of Natural History</em> 35(9): 1261-1276.<br /></p>
<p>Lopez, Jose V., Peter J. McCarthy, Kathleen E. Janda, Robin Willoughby and Shirley A. Pomponi. 1999. Molecular techniques reveal wide phyletic diversity of heterotrophic microbes associated with <em>Discodermia</em> spp. (Porifera: Demospongiae). <em>Memoirs of the Queensland Museum</em> 44: 329-340.<br /></p>
<p>Willenz, Philippe, and Shirley A. Pomponi. 1996. A new deep sea coralline sponge from Turks and Caicos Islands: <em>Willardi caicosensis</em> gen. and sp. nov. (Demospongiae: Hadromerida). IN: Proceedings of the Xth Workshop on Atlanto-Mediterranean Sponge Taxonomy (Willenz, P. ed.).<em>Bulletin Del ’Institut Royal Des Sciences Naturelles De Belgique</em> 66(suppl.) 205-218.<br /></p>
<p>Kelly-Borges, Michelle. and Shirley A. Pomponi. 1994. Phylogeny and classification of lithistid sponges (Porifera: Demospongiae): a preliminary assessment using ribosomal DNA sequence comparisons. <em>Molecular Marine Biology and Biotechnology</em> 3(2): 87-103.<br /></p>
<p>Kelly-Borges, Michelle, Elise V. Robinson, Sarath P. Gunasekera, Malika Gunasekera, Nanda K. Gulavita and Shirley A. Pomponi. 1994. Species differentiation in the marine sponge genus <em>Discodermia</em> (Demospongiae, Lithistida): the utility of ethanol extract profiles as species-specific chemotaxonomic markers. <em>Biochemical Systematics and Ecology</em> 22(4): 353-365.<br /></p>
<p>Kelly-Borges, Michelle, Shirley A. Pomponi and Jean Vacelet. 1993. <em>Spongionella foliascens</em>: a new foliose dendroceratid sponge from the western Atlantic. <em>Scientia Marina</em> 57(4): 375-379.<br /></p>
<p>Diaz, Maria Cristina, Shirley A. Pomponi and R.W.M. van Soest. 1993. A systematic revision of the west central west Atlantic Halichondrida (Demospongiae, Porifera). Part III: Description of valid species. <em>Scientia Marina</em> 57(4): 283-306.<br /></p>
<p>Pomponi, S.A., A.E. Wright, M.C. Diaz and R.W.M. Van Soest. 1991. A systematic revision of the central Atlantic Halichondrida (Demospongiae, Porifera). Part II: Patterns of distribution of secondary metabolites. IN:<em>Proceedings, International Conference on Fossil and Recent Sponges</em>. Editors: J. Reitner and H. Keupp. Berlin, Springer-Verlag, c1991. pp. 150-158.<br /></p>
<p>Diaz, M.C., R.W.M. Van Soest and S.A. Pomponi. 1991. A systematic revision of the central Atlantic Halichondrida (Demospongiae, Porifera). Part I: Evaluation of characters and diagnosis of genera. IN: <em>Proceedings, International Conference on Fossil and Recent Sponges.</em> Editors: J. Reitner and H. Keupp. Berlin, Springer-Verlag, c1991. pp. 134-158.<br /></p>
<p>Soest, R.W.M. van, Maria Cristina Diaz and Shirley A. Pomponi. 1990. Phylogenetic classification of the Halichondrids (Porifera, Demospongia). <em>Beaufortia</em> 40(2): 15-62.<br /></p>
<p>Harasewych, M.G., Shirley A. Pomponi and Timothy M. Askew. 1988. The diet of two species of pleurotomariid gastropods from the western Atlantic. <em>The Nautilus</em>. 102(3): 92-98.<br /></p>
<p>Pomponi, Shirley A. and Donald W. Merritt. Distribution and life history of the boring sponge <em>Cliona truitti</em> in the Upper Chesapeake Bay. 1990. In: Klaus Ruetzler, ed. New <em>Perspectives in Sponge Biology</em>, Smithsonian Institution Press, Washington, D.C., pp. 384-390.<br /></p>
<h4>Marine Biotechnology<br /></h4>
<p>Pomponi, S.A., Baden, D.G., and Zohar, Y. 2007. Marine Biotechnology: realizing the potential. <em>Marine Technology Society Journal.</em> 41(3): 24-31.<br /></p>
<p>Duckworth, Alan and Shirley A. Pomponi. 2005. Relative importance of bacteria, microalgae and yeast for growth of the sponge <em>Halichondria melanadocia</em> (De Laubenfels, 1936): a laboratory study. <em>Journal of Experimental Marine Biology and Ecology</em> 323: 151-159.<br /></p>
<p>Duckworth, Alan R., Gail A. Samples, Amy E. Wright and Shirley A. Pomponi. 2003. <em>In vitro</em> culture of the tropical sponge <em>Axinella corrugata</em> (Demospongiae): effect of food cell concentration on growth, clearance rate and biosynthesis of stevensine. <em>Marine Biotechnology</em> 5: 519-527.<br /></p>
<p>Pomponi, Shirley A. 2001. The Roger Revelle Commemorative Lecture. The oceans and human health: The discovery and development of marine-derived drugs. <em>Oceanography</em>. Vol. 14(1): 78 – 87.<br /></p>
<p>Wijffels, R.H., Osinga, R., Pomponi, S., and Tramper, J. 2001. Marine sponges as biocatalysts. IN <em>Multiphase Bioreactor Design</em>. Edited by J.M.S. Cabral, M. Mota, and J. Tramper. Taylor & Francis, London and New York, pp. 477-493.<br /></p>
<p>Reed, John K. and Shirley A. Pomponi. 2000. Sustainable use of deep-sea organisms collected for biomedical research. <em>Proceedings of the Marcuba 2000, 5</em><sup><em>TH</em></sup><em>Congress on Marine Sciences,</em> Havana, Cuba, December 4-8, 2000. (CD-ROM). 11 pp.<br /></p>
<p>Pomponi, Shirley A. The bioprocess – technological potential of the sea. 1999. <em>Journal of Biotechnology</em>. 70:5-13.<br /></p>
<p>Reed, John K. and Shirley A. Pomponi. 1989. Biomedical research in the sea, a search for drugs and novel compounds. IN: <em>Diving for Science 1989: Ninth Annual Scientific Diving Symposium.</em> Editors: Michael A. Lang and Walter C. Jaap. Costa Mesa, California, American Academy of Underwater Sciences, c1989. pp. 273-287.<br /></p>
<p>Pomponi, Shirley A. 1988. Maximizing the potential of marine organism collections for both pharmacological and systematic studies. <em>Memoirs of the California Academy of Sciences</em> 13: 7-11.<br /></p>
<h4>Marine natural products chemistry<br /></h4>
<p>Wright, A., Botelho, J. Cook, Guzmán, E., Harmody, D., Linley, P., McCarthy, P.J., Pitts, T.P., Pomponi, S.A. and Reed, J.K. 2007. Neopeltolide a Macrolide from a Lithistid Sponge of the Family Neopeltidae J. Nat. Prod. 70: 412-416.<br /></p>
<p>Wright, Amy E., Ying Chen, Priscilla L. Winder, Tara A. Pitts, Shirley A. Pomponi and Ross E. Longley. 2004. Lasonolides C-G: five new lasonolide compounds from the sponge <em>Forcepia</em>. <em>Journal of Natural Products</em> 67: 1351-1355.<br /></p>
<p>Cohen, Jesse, Gopal K. Paul, Sarath P. Gunasekera, Ross E. Longley and Shirley A. Pomponi. 2004. 6-Hydroxydiscodermindole, a new discodermindole from the marine sponge <em>Discodermia polydiscus</em>. <em>Pharmaceutical Biology</em> 42(1): 59-61.<br /></p>
<p>Gunasekera, Sarath P., Richard A. Isbrucker, Ross E. Longley, Amy E. Wright, Shirley A. Pomponi and John K. Reed. 2004. Plakolide A, a new <em>?</em>-lactone from the marine sponge <em>Plakortis</em> sp. <em>Journal of Natural Products</em> 67: 110-111.<br /></p>
<p>Isbrucker, Richard A., Jennifer Cummins, Shirley A. Pomponi, Ross E. Longley and Amy E. Wright. 2003. Tubulin polymerizing activity of Dictyostatin-1, a polyketide of marine sponge origin. <em>Biochemical Pharmacology</em> 66(1): 75-82<br /></p>
<p>Gunasekera, Sarath P., Ignacio A. Zuleta, Ross E. Longley, Amy E. Wright and Shirley A. Pomponi. 2003. Discorhabdins S, T and U: new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella. <em>Journal of Natural Products</em> 66: 1615-1617.<br /></p>
<p>Yang, S.W., A. Buivich, T.M. Chan, M. Smith, J. Lachowicz, S.A. Pomponi, A.E. Wright, R. Mierzwa, M. Patel, V. Gullo and M.A. Chu. 2003. A new sterol sulfate, Sch 572423 from a marine sponge, <em>Topsentia</em> sp. <em>Bioorganic and Medicinal Chemistry Letters</em> 13(10): 1791-1794.<br /></p>
<p>Yang, Shu-Wei, Tze-Ming Chan, Shirley A. Pomponi, Guodong Chen, Amy E. Wright, Mahesh Patel, Vincent Gullo, Birendra Pramanik and Min Chu. 2003. A new bicyclic guanidine alkaloid, Sch 575948, from a marine sponge, <em>Ptilocaulis spiculifer</em>. <em>Journal of Antibiotics</em> 56(11): 970-972.<br /></p>
<p>Yang, Shu-Wei, Tze-Ming Chan, Shirley A. Pomponi, Waldemar Gonsiorek, Guodong Chen, Amy E. Wright, William Hipkin, Mahesh Patel, Vincent Gullo, Birendra Pramanik, Paul Zavodny and Min Chu. 2003. A new sesterterpene, Sch 599473, from a marine sponge, <em>Ircinia</em> sp. <em>Journal of Antibiotics</em> 56(9): 783-786.<br /></p>
<p>Paul, Gopal K., Sarath P. Gunasekera, Ross E. Longley and Shirley A. Pomponi. 2002. Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge <em>Discodermia</em> species. <em>Journal of Natural Products</em> 65(1): 59-61.<br /></p>
<p>Biabani, Misbah F., Sarath P. Gunasekera, Ross E. Longley, Amy E. Wright and Shirley A. Pomponi. 2002. Tubercidin, a cytotoxic agent from the marine sponge <em>Caulospongia bifflabellata</em>. <em>Pharmaceutical Biology</em> 40(4): 302-303.<br /></p>
<p>Chen, Ying, Peter J. McCarthy, Dedra K. Harmody, Rebecca Schimoler-O’Rourke, Katherine Chilson, Claude Selitrennikoff, Shirley A. Pomponi and Amy E. Wright. 2002. New bioactive peroxides from marine sponges of the family Plakiniidae. <em>Journal of Natural Products</em> 65: 1509-1512.<br /></p>
<p>Gunasekera, Sarath P., Gopal K. Paul, Ross E. Longley, Richard A. Isbrucker and Shirley A. Pomponi. 2002. Five new Discodermolide analogues from the marine sponge <em>Discodermia</em> species. <em>Journal of Natural Products</em> 65: 1643-1648.<br /></p>
<p>Peppard, Jane V., Patricia Loo, Matthew A. Sills, Lawrence Wennogle, Amy Wright, Shirley Pomponi and Maria Cueto. 2001. The discovery and characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, <em>Callyspongia sp.</em> IN: <em>Phylogenetic Perspectives on the Vertebrate Immune System (Advances in experimental medicine and biology, v. 484)</em>. Editors: Gregory Beck, et al. New York, Kluwer Academic, c2001. pp. 77-87.<br /></p>
<p>Chen, Ying, K. Brian Killday, Peter J. McCarthy, Rebecca Schimoler, Katherine Chilson, Claude Selitrennikoff, Shirley A. Pomponi and Amy E. Wright. 2001. Three new peroxides from the sponge <em>Plakinastrella</em> sp<em>.</em> <em>Journal of Natural Products</em>, 64(2):262-264.<br /></p>
<p>Stead, Paul, Steve Hiscox, Phil S. Robinson, Nicholas B. Pike, Philip J. Sidebottom, Andrew D. Roberts, Nicholas L. Taylor, Amy E. Wright, Shirley A. Pomponi, and David Langley. 2000. Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity. <em>Bioorganic & Medicinal Chemistry Letters</em> 10:661-664.<br /></p>
<p>Giner, Jose-Luis, Sarath P. Gunasekera, and Shirley A. Pomponi. 1999. Sterols of the marine sponge <em>Petrosia weinbergi</em>: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols. <em>Steroids</em> 64: 820-824.<br /></p>
<p>Gunasekera, Sarath P., Peter J. McCarthy, Ross E. Longley, Shirley A. Pomponi and Amy E. Wright. 1999. Secobatzellines A and B, two new enzyme inhibitors from a deep water Caribbean sponge of the genus <em>Batzella</em>. <em>Journal of Natural Products</em>, 62:(8):1208-1211.<br /></p>
<p>Gunasekera, S., Peter J. McCarthy, Ross E. Longley, Shirley A. Pomponi and Amy E. Wright. 1999. Discorhabdin-P: A new enzyme inhibitor from a deep water Caribbean sponge of the genus <em>Batzella</em>. <em>Journal of Natural Products</em>. 62(1):173-175.<br /></p>
<p>Wood, Rebecca, Amy Wright, Peter McCarthy, Tamara K. Miller, Cathy S. Taft, Shirley Pomponi, and Claude P. Selitrennikoff. 1998 Characterization and optimization of <em>in vitro</em> assay conditions for (1,3)beta-glucan synthase activity form <em>Aspergillus fumigatus</em> and <em>Candida albicans</em> for enzyme inhibition screening. <em>Journal of Antibiotics</em>. 51(7):665-675.<br /></p>
<p>O'Keefe, B.R., John A. Beutler, John H. Cardellina II, Robert J. Gulakowshi, Benjamin. L. Krepps, James B. McMahon, Raymond C. Sowder II, Louis E. Henderson, Lewis K. Pannell, Shirley A. Pomponi, and Michael R. Boyd. 1997. Isolation and characterization of Niphatevirin, a novel HIV-inhibitory glycoprotein from the marine sponge <em>Niphates erecta</em>. <em>European Journal of Biochemistry</em> 245(1): 47-53.<br /></p>
<p>Peppard, Jane, V., Patricia Loo, Matthew A. Sills, Deborah Munster, Shirley A. Pomponi, and Amy E. Wright. 1996. Characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, <em>Callyspongia</em> sp. <em>Journal of Biological Chemistry</em>. 271(13):7281-7284.<br /></p>
<p>Gulavita, Nanda K., Amy E. Wright, Peter J. McCarthy, Shirley A. Pomponi, and Ross E. Longley. 1996. Cytotoxic peptides from marine sponges. <em>Journal of Natural Toxins</em>. 5(2): 225-234.<br /></p>
<p>Gulavita, Nanda K., Shirley A. Pomponi, Amy E. Wright, Michelle Garay and Matthew A. Sills. 1995. Aplysillin A, a thrombin receptor antagonist from the marine sponge, <em>Aplysina fistularis fulva</em>. <em>Journal of Natural Products</em> 58(6): 954-957.<br /></p>
<p>Coval, Stephen J., Michael A. Conover, Ronald Mierzwa, Arthur King, Mohindar S. Puar, David W. Phife, Jin-Keon Pai, Robert E. Burrier, Ho-Sam Ahn, George C. Boykow, Mahesh Patel and Shirley A. Pomponi. 1995. Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge <em>Xestospongia wiedenmayeri</em>. <em>Bioorganic & Medicinal Chemistry Letters</em> 5(6): 605-610.<br /></p>
<p>Gulavita, Nanda K., Shirley A. Pomponi, Amy E. Wright, Donna Yarwood and Matthew A. Sills. 1994. Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge <em>Theonella</em> sp. <em>Tetrahedron Letters</em> 35(37): 6815-6818.<br /></p>
<p>Mierzwa, Ronald, Arthur King, Michael A. Conover, Salvatore Tozzi, Mohindar S. Puar, Mahesh Patel, Stephen J. Coval and Shirley A. Pomponi. 1994. Verongamine, a novel bromotyrosine derived histamine h<sub>3</sub>-antagonist from the marine sponge <em>Verongula gigantea</em>. <em>Journal of Natural Products</em> 57(1):175-177.<br /></p>
<p>Gunasekera, Sarath P., Shirley Pomponi and Peter McCarthy. 1994. Discobahamins A and B, new peptides from the Bahamian deep water marine sponge <em>Discodermia</em> sp. <em>Journal of Natural Products</em> 57(1): 79-83.<br /></p>
<p>Gulavita, Nanda K, Amy E.Wright, Peter J. McCarthy, Shirley A. Pomponi, and Michelle Kelly-Borges. 1993. Isolation and structure elucidation of 34-sulfatobastadin-13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus <em>Ianthella</em>. <em>Journal of Natural Products</em> 56(9): 1613-1617.<br /></p>
<p>Killday, K. Brian, Ross Longley, Peter J. McCarthy, Shirley A. Pomponi, Amy E. Wright, Robert F. Neale andd Matthew A. Sills. 1993. Sesquiterpene-derived metabolites from the deep water marine sponge <em>Poecillastra sollasi</em>. <em>Journal of Natural Products</em> 56(4): 500-507.<br /></p>
<p>McCarthy, Peter J., Tara P. Pitts, Geewananda P. Gunawardana, Michelle Kelly-Borges and Shirley A. Pomponi. 1992. Antifungal activity of meridine, a natural product from the marine sponge <em>Corticium</em> sp. <em>Journal of Natural Products</em> 55(11): 1664-1668.<br /></p>
<p>Sennett, Susan H., Shirley A. Pomponi and Amy E. Wright. 1992. Diterpene metabolites from two chemotypes of the marine sponge <em>Myrmekioderma styx</em>. <em>Journal of Natural Products</em> 55(10): 1421-1429.<br /></p>
<p>Wright, Amy E., Shirley A. Pomponi, Sue S. Cross and Peter McCarthy. 1992. A new bis(indole) alkaloid from a deep-water marine sponge of the genus <em>Spongosorites</em>. <em>Journal of Organic Chemistry</em> 57: 4772-4775.<br /></p>
<p>Gulavita, Nanda K., Sarath P. Gunasekera, Shirley A. Pomponi and Elise V. Robinson. 1992. Polydiscamide A: a new bioactive depsipeptide from the marine sponge, <em>Discodermia</em> sp. <em>Journal of Organic Chemistry</em> 57: 1767-1772.<br /></p>
<p>Gulavita, Nanda K., Sarath P. Gunasekera and Shirley A. Pomponi. 1992. Isolation of latrunculin A,6,7-epoxylatrunculin A, fijianolide A and euryfuran from a new genus of the family Thorectidae. <em>Journal of Natural Products</em> 55(4): 506-508.<br /></p>
<p>Gunasekera, Sarath P., Sue S. Cross, Ross E. Longley and Shirley A. Pomponi. 1991. The chemistry and biological activity of five marine sponges of the genus <em>Aplysina</em>. IN: <em>Progress on Terrestrial and Marine Natural Products of Medicinal and Biological Interest.</em> Editors: John M. Pezzuto, et al. Chicago, Illinois, University of Illinois at Chicago, 1991. pp. 53-58.<br /></p>
<p>Tsujii, Shinji, Kenneth L. Rinehart, Sarath P. Gunasekera, Yoel Kashman, Susan S. Cross, May S. Lui, Shirley A. Pomponi and M. Christina Diaz. 1988. Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin; antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies. <em>Journal of Organic Chemistry</em> 53(23): 5446-5453.<br /></p>
<p>Wright, Amy E., Shirley A. Pomponi, Oliver J. McConnell, Shigeo Kohmoto and Peter J. McCarthy. 1987. (+)-Curcuphenol and (+)-curcudiol, sesquiterpene phenols from shallow and deep water collections of the marine sponge <em>Didiscus flavus</em>. <em>Journal of Natural Products</em> 50(5): 976-978.</p>
Harbor Branch
Shirley Pomponi