FAU - Esther A. Guzman, Ph.D.

			ABOUT HARBOR BRANCH

			FRIENDS OF HARBOR BRANCH

			OCEAN DISCOVERY CENTER

			EDUCATION



			Ocean Technology Ocean Visibility and Optics Lab (OVOL) Harris Ocean Net Buoys Aquarius Raytheon Tower MPS Program Ver. 2 BP Drifter DRONE Swarming ASVs Eye-in-the-Sea on MARS LoLar II Deep Ocean Australia Eye-in-the-Sea HIDEX Gen 3 Nemesis ROV

			Marine Drug Discovery Collection Marine Biotechnology Drug Discovery Project

			Aquaculture Aquaculture for Food Aquaculture for Stock Enhancement Aquaculture Education Aquatic Animal Health Lab

			Ocean Exploration Deep Reefs Natural Resources Visual Ecology CIOERT

			Ocean Health Harmful Algal Blooms Indian River Lagoon Marine Mammals Polar Research Coral Reefs Population Biology and Behavioral Ecology

JANUARY 2013

Thur, Jan 10

VIP Tour for HBOI/Members & Guests-Reservations required. 10am-11:30am. Meet at the Ocean Discovery Center at 9:30am. Tour: Coral Reef Research Labs.(772) 242-2559 for information and reservations.

Sat, Jan 12

Spoil Island Clean-up. Depart Johnson Education Center at 8:30am, return at 12:30pm. Call (772) 242-2559 for information and reservations.

Wed, Jan 16 - Wed, Apr 3, 2013

Ocean Science Lecture Series, each Wednesday evening at 4 p.m. and 7 p.m. at the Johnson Education Center.

Thur, Jan 17

Tour Florida's Newest Winery - Endless Summer Vineyard and Winery, Ft. Pierce. Depart HBOI at 10:30am, return at 1:00pm. $30 for members, $35 for nonmembers. Call (772) 242-2559 for information and reservations.

Thur, Jan 24

Explore the Kissimmee - Depart HBOI at 9:00am, return at 3:00pm. Transportation and lunch included. $40 for members, $50 for nonmembers. Limited seating - call (772) 242-2559 for information and reservations.

SAVE THE DATE

Wed, Jan 30, 2013

OSLS *Special Guest Speaker* Dr. Rita R. Colwell, Chairman, Canon US Life Sciences, Inc. and Distinguished Professor, University of Maryland College Park and Johns Hopkins University Bloomberg School of Public Health. Ocean Science Lecture Series, 7 p.m. at the Johnson Education Center. Free Admission.

SAVE THE DATE

Love Your Lagoon

February 6-8

Wed Feb 6 - 6:30 pm at St. Edwards School - HBOI OSLS in Partnership with the Yale Club of the Treasure Coast: Sir Peter Crane, Dean of the Yale School of Forestry and Environmental Studies

Thursday, Feb 7 - IR Lagoon Symposium 2013 Community encouraged to “Meet the Scientists” poster session from 5:30 p.m. – 7 p.m.

Friday, Feb 8 Forum on Lagoon Health 9 a.m - 12 p.m.

Friday, Feb 8 – “Love Your Lagoon” Dinner

For more information: www.indianriverlagoon.org

FAU CALENDARS

Esther A. Guzmán, Ph.D.

Assistant Research Professor

eguzman9@hboi.fau.edu
772-242-2452

Education

2004, Ph.D. Immunology,
University of Texas MD Anderson Cancer Center, Houston, Texas.

1996, B.S. Molecular Biology/Biotechnology,
Salem-Teikyo University, Salem, West Virginia.

Career

1993 Student Fellow; Howard Hughes Medical Institute Summer Fellowship; West Virginia University, Morgantown, West Virginia

1995-1996 Independent Researcher, Salem-Teikyo University, Salem, West Virginia

1996-1997 Graduate Research Assistant, Theoretical Biology and Biophysics Division; HIV Database, Los Alamos National Laboratory, Los Alamos, New Mexico

1997-2001 Graduate Research Assistant, University of Texas M.D. Anderson Cancer Center, Houston, Texas

2001-2004 Graduate Research Assistant, University of California, Riverside, California

2004- 2005 Postdoctoral Fellow, Henry Ford Health System, Detroit, Michigan

2005-2007 Postdoctoral Investigator, Harbor Branch Oceanographic Institution, Ft.Pierce, Florida

2007 Assistant Research Scientist, Harbor Branch Oceanographic Institution, Ft. Pierce, Florida

2008-present Assistant Research Professor Harbor Branch Oceanographic Institute at FAU

Detailed CV

Research Interests

My research focuses on finding marine natural products that have the potential to be novel therapeutics against pancreatic cancer, novel drugs that target components of the immune system that link inflammation and pancreatic cancer development or novel tools to help us further our understanding of this dreaded disease. Pancreatic cancer is the fourth leading cause of cancer lethality in the United States. Patients diagnosed have a survival rate of 26% one year after diagnosis and less than 6% five years after diagnosis, highlighting the urgent need for new therapies to treat this disease. My work at Harbor Branch has resulted in the discovery of novel anti-metastatic properties for manzamine A; the inhibition of topoisomerase II by isobatzelline E; the anti-mitotic effects of aphrocallistin and its derivatives, the inhibition of NFκB by spongiatriol and microsclerodermin A, and the development of assays to detect compounds that target important signaling pathways that are aberrant in pancreatic cancer. This work has resulted in 11 publications and 2 patents.